Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Long-term Potentiation01:35

Long-term Potentiation

58.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.9K
Long-term Potentiation01:25

Long-term Potentiation

3.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.7K
Long-term Depression01:03

Long-term Depression

3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Long-term Depression01:05

Long-term Depression

33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Chemical Synapses01:26

Chemical Synapses

4.8K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
4.8K
Chemical Synapses01:26

Chemical Synapses

12.1K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
12.1K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

An unsuspected physiological role for mGluRIII glutamate receptors in hippocampal area CA1.

Cell reports·2026
Same author

Hippocampal Place Cells with NMDARs Do Not Require Excitation and Inhibition to Be Reciprocally Tuned.

bioRxiv : the preprint server for biology·2026
Same author

Subicular Plateaus Signal Reward Locations during Goal-Directed Behavior.

bioRxiv : the preprint server for biology·2026
Same author

Behavioral timescale synaptic plasticity: properties, elements and functions.

Nature neuroscience·2026
Same author

Learning-dependent feedback by OLM interneurons shapes CA1 representations.

bioRxiv : the preprint server for biology·2026
Same author

Sexual dimorphism in the complete connectome of the <i>Drosophila</i> male central nervous system.

bioRxiv : the preprint server for biology·2025
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Feb 23, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K

La plasticidad sináptica de la escala de tiempo del comportamiento subyace a los campos de lugar CA1

Katie C Bittner1, Aaron D Milstein1,2, Christine Grienberger1

  • 1Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA 20147, USA.

Science (New York, N.Y.)
|September 9, 2017
PubMed
Resumen
Este resumen es generado por máquina.

Los científicos descubrieron una nueva forma de plasticidad sináptica, llamada plasticidad sináptica de escala de tiempo conductual, que ayuda a crear campos de lugar en el cerebro. Este proceso permite el aprendizaje rápido de secuencias mediante la modificación de la fuerza sináptica, incluso cuando las entradas no están directamente vinculadas al disparo de las neuronas.

Más Videos Relacionados

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

16.4K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.9K

Videos de Experimentos Relacionados

Last Updated: Feb 23, 2026

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

13.5K
Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

16.4K
Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.9K

Área de la Ciencia:

  • La neurociencia
  • Plasticidad sináptica
  • Aprendizaje y memoria

Sus antecedentes:

  • La plasticidad sináptica es crucial para el aprendizaje y la memoria, principalmente a través de modificaciones dependientes de la actividad de la fuerza sináptica.
  • Los modelos existentes como la plasticidad de Hebbian se basan en la actividad pre- y postsináptica coincidente.
  • Los mecanismos subyacentes a la rápida formación de campos de lugar en el hipocampo siguen siendo incompletamente entendidos.

Objetivo del estudio:

  • Investigar los mecanismos sinápticos responsables de la formación de campos de lugar en el área del hipocampo CA1.
  • Identificar nuevas formas de plasticidad sináptica más allá de las reglas Hebbianas tradicionales.
  • Para entender cómo los circuitos neuronales aprenden y representan la información secuencial.

Principales métodos:

  • Electrofisiología in vivo en el área del hipocampo CA1 para observar la formación del campo local.
  • Electrofisiología de corte in vitro para caracterizar la inducción de la plasticidad sináptica y el curso temporal.
  • Utilizando potenciales de meseta de calcio y estimulación presináptica de subumbral.

Principales resultados:

  • Se identificó una nueva forma de potenciación sináptica, denominada plasticidad sináptica a escala de tiempo conductual (BTSP).
  • BTSP puede inducir campos de lugar in vivo en un solo ensayo, independientemente de la coincidencia temporal estricta con los potenciales de acción.
  • Esta plasticidad exhibe un curso de tiempo asimétrico de segundos, potenciando las entradas que llegan segundos antes o después del pico complejo.
  • En rebanadas, la BTSP fue inducida mediante el emparejamiento de la actividad presináptica subumbral con los potenciales de meseta de calcio.

Conclusiones:

  • La plasticidad sináptica a escala de tiempo conductual ofrece un mecanismo para codificar rápidamente información secuencial en pesos sinápticos.
  • Esta regla de plasticidad se desvía de los principios de Hebbian, permitiendo la potenciación de entradas que no preceden inmediatamente a la activación postsináptica.
  • BTSP proporciona un marco para comprender cómo surge la actividad predictiva de las células de lugar a partir de la experiencia.