Video Experimental Relacionado
Updated: Aug 8, 2026
07:13
Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
Published on: March 25, 2016
Efecto de la bacteriuria asintomática en la infancia en el embarazo posterior
S H Sacks1, K Verrier Jones, R Roberts
1Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford.
Lancet (London, England)
|October 31, 1987
Resumen
Las mujeres con antecedentes de infecciones del tracto urinario infantil (ITU) enfrentan mayores riesgos durante el embarazo, incluidas mayores tasas de pielonefritis aguda y preeclampsia, especialmente si hay cicatrices en los riñones. Las puntuaciones de Apgar infantil también fueron más bajas en estos embarazos.
Área de la Ciencia:
- Obstetricia y Ginecología.
- Enfermedades infecciosas Enfermedades infecciosas.
- La pediatría es la medicina de los niños.
Sus antecedentes:
- Las infecciones urinarias infantiles (ITU) pueden tener implicaciones a largo plazo para la salud.
- Las infecciones urinarias recurrentes o las que conducen a la cicatrización renal pueden afectar los resultados futuros del embarazo.
- Comprender estos riesgos es crucial para la gestión de la salud materna e infantil.
Objetivo del estudio:
- Para comparar los resultados del embarazo en mujeres con antecedentes de bacteriuria infantil frente a controles sanos.
- Para investigar el impacto de infecciones urinarias previas y cicatrices renales en las complicaciones del embarazo.
- Evaluar los efectos sobre la salud materna, el modo de parto y el bienestar del bebé.
Principales métodos:
- Se utilizó un diseño de estudio comparativo.
- Los resultados del embarazo se rastrearon para 34 mujeres con antecedentes de bacteriuria infantil (52 embarazos) y se compararon con embarazos de control normales.
- Los principales resultados evaluados incluyeron la prevalencia de bacteriuria, pielonefritis, preeclampsia, intervenciones de parto y puntajes de Apgar en bebés.
Principales resultados:
- Las mujeres previamente bacteriúricas tuvieron tasas significativamente más altas de bacteriuria (35% vs 5%) y pielonefritis aguda (10% vs 4%) durante el embarazo.
- La preeclampsia se produjo con mayor frecuencia en mujeres previamente bacteriúricas con cicatrización renal (p < 0,001).
- Las mujeres con cicatrices renales eran más propensas a someterse a la inducción del trabajo de parto (44%) y al parto quirúrgico (57%); sus bebés tenían puntuaciones Apgar más bajas.
Conclusiones:
- Un historial de bacteriuria infantil, particularmente con cicatrización renal, se asocia con un mayor riesgo de pielonefritis y preeclampsia durante el embarazo.
- La cicatrización renal en mujeres previamente bacteriúricas se correlaciona con tasas más altas de intervenciones obstétricas y puntuaciones de Apgar infantiles más bajas.
- Si bien los resultados fetales fueron satisfactorios, se justifica un monitoreo cuidadoso para las mujeres embarazadas con antecedentes de infecciones urinarias infantiles.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by anesthetizing...
01:22Development of Immunocompetence
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
01:30Development of Human Microbiota
The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
01:28Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
01:21Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...