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Historias evolutivas alternativas en el espacio de secuencia de una proteína antigua

Tyler N Starr¹, Lora K Picton², Joseph W Thornton^2,3

¹Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA.

|September 14, 2017

Resumen

Evolución molecular

Área de la Ciencia:

Biología evolutiva
Evolución molecular
La bioquímica

Sus antecedentes:

Comprender la evolución molecular requiere examinar las vías evolutivas reales y potenciales.
La distinción entre la optimización impulsada por la selección y la contingencia histórica es crucial.

Objetivo del estudio:

Para investigar las trayectorias evolutivas alternativas en el espacio de secuencia de proteínas.
Para determinar cómo los paisajes funcionales y el azar histórico dan forma a los resultados evolutivos.

Principales métodos:

Reconstrucción de proteínas ancestrales
Escaneo mutativo profundo
Análisis del espacio de secuencia de proteínas

Principales resultados:

Cientos de secuencias de proteínas alternativas pueden realizar la función derivada de manera efectiva.
Los caminos alternativos requieren sustituciones permisivas, pero no siempre las mismas.
Los resultados evolutivos dependen de los puntos de partida y los eventos históricos casuales.

Conclusiones:

La inmensidad del espacio de secuencia permite numerosas variantes funcionales.
La epistasis y la distribución de las funciones contribuyen a la contingencia evolutiva.
La evolución molecular está formada por una serie de eventos casuales compuestos.

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