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Regulación del genoma por policombo y tritórax: 70 años y contando

Bernd Schuettengruber1, Henri-Marc Bourbon2, Luciano Di Croce3

  • 1Institute of Human Genetics, UMR9002 CNRS, University of Montpellier, 141 Rue de la Cardonille, 34396 Montpellier Cedex 5, France.

Cell
|September 23, 2017
PubMed
Resumen

Las proteínas Polycomb (PcG) y Trithorax (TrxG) son reguladores epigenéticos clave que mantienen la expresión génica. Sus diversos roles en la estructura de la cromatina y la organización del genoma son cruciales para los procesos celulares e implicados en enfermedades como el cáncer.

Palabras clave:
el cáncermemoria celularCromatina y sus derivadosdesarrolloLa epigenéticaArquitectura nuclearel policombradotranscripciónherencia epigenética transgeneracionalel trithorax

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