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Anticorpos xenogénicos y enfermedades atópicas
1Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
Lancet (London, England)
|April 2, 1988
Resumen
Los anticuerpos xenogénicos de los alimentos sobreviven a la digestión y pueden afectar el sistema inmunológico humano. Esto puede explicar las alergias a sustancias ambientales como el polen, relacionadas con el consumo de productos lácteos.
Área de la Ciencia:
- Inmunología Inmunología.
- Ciencias de la alimentación Ciencias de la alimentación.
Sus antecedentes:
- Los anticuerpos xenogénicos pueden sobrevivir al procesamiento de alimentos, manteniendo la actividad biológica.
- Estos anticuerpos pueden ser absorbidos desde el intestino, funcionando como antígenos y anticuerpos en humanos.
- Los anticuerpos contra la gamma globulina bovina (BGG), incluidos los antiidiotípicos, se encuentran en el suero humano.
Objetivo del estudio:
- Proponer una hipótesis sobre cómo los anticuerpos xenogénicos priman el sistema inmunológico humano.
- Explorar el vínculo entre los anticuerpos xenogénicos dietéticos y las alergias a los alérgenos ambientales.
Principales métodos:
- Revisión de la literatura y formulación de hipótesis.
- Análisis de la absorción de anticuerpos y la función inmune.
Principales resultados:
- Los anticuerpos xenogénicos pueden ser absorbidos e influir en el sistema inmunológico humano.
- La exposición de bajo nivel puede preparar el sistema inmunológico para respuestas inapropiadas a los alérgenos.
- Los productos lácteos son una fuente significativa de anticuerpos xenogénicos en la dieta.
Conclusiones:
- Los anticuerpos xenogénicos en los alimentos pueden contribuir a las alergias más allá de las proteínas lácteas.
- La exposición dietética a anticuerpos xenogénicos podría explicar las asociaciones con alergias ambientales.
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