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Formación dirigida por la conformación de hidrogeles de copolipéptidos dibloqueados de autocuración a través de la

Yintao Sun¹, Alexander L Wollenberg¹, Timothy Mark O'Shea¹

¹Department of Bioengineering, ‡Department of Chemistry and Biochemistry, §Department of Neurobiology, David Geffen School of Medicine, ∥California NanoSystems Institute, and ⊥Department of Microbiology, Immunology and Molecular Genetics, University of California , Los Angeles, California 90095, United States.

Journal of the American Chemical Society

|October 5, 2017

Resumen

Los investigadores crearon hidrogeles de autocuración utilizando copolíptidos sintéticos que forman estructuras de hojas beta ordenadas. Este ensamblaje controlado ofrece propiedades únicas como microporosidad y estabilidad, avanzando en el diseño de materiales supramoleculares.

Área de la Ciencia:

Ciencias de los Polímeros
Ciencias de los materiales
Ingeniería de Biomateriales

Sus antecedentes:

Los materiales autoensamblados son cruciales para aplicaciones avanzadas.
Los ensamblajes de complejos poliiónicos (PIC) existentes a menudo usan estructuras desordenadas.
El desarrollo de ensamblajes PIC ordenados puede dar lugar a nuevas propiedades de los materiales.

Objetivo del estudio:

Diseñar copolipéptidos sintéticos para la formación de hidrogel ordenado.
Investigar el papel de la conformación de la cadena en el ensamblaje de hidrogel de complejo poliiónico (PIC).
Explorar las propiedades de los hidrogeles PIC estructurados en hojas beta.

Principales métodos:

Síntesis de copolipéptidos de doble bloqueo con segmentos iónicos de carga opuesta.
Mezcla de copolipéptidos en un medio acuoso para inducir su autoensamblaje mediante la complejación de poliiones.
Caracterización de la estructura del hidrogel, la autocuración, la microporosidad y la estabilidad.

Principales resultados:

Se formaron con éxito conjuntos de hidrogel estructurados en hojas beta a través de la complejación controlada de poliiones.
Se ha demostrado que el ensamblaje dirigido por la conformación de la cadena es esencial para la formación eficiente de hidrogel.
Se observaron propiedades únicas del hidrogel: autocuración, arquitectura microporosa y estabilidad frente a la dilución.

Conclusiones:

Las conformaciones de cadenas ordenadas en ensamblajes PIC pueden dirigir la formación de nuevas morfologías supramoleculares.
Los hidrogeles PIC estructurados en hojas beta exhiben atributos prometedores y características únicas.
El aprovechamiento del orden conformacional en el ensamblaje PIC ofrece un camino hacia nuevos materiales supramoleculares.

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