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Estructura del canal endolisomal TRPML1 de los mamíferos en los nanodiscos

Qingfeng Chen1,2,3, Ji She1,2, Weizhong Zeng1,2,3

  • 1Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9040, USA.

Nature
|October 12, 2017
PubMed
Resumen

La estructura del canal TRPML1 revela cómo el fosfatidilinositol-3,5-bisfosfato (PtdIns(3,5) P2) regula su función, ofreciendo información sobre enfermedades de almacenamiento lisosomal como la mucolipidosis.

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