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Apoyo a la hipótesis de la adrenalina-hipertensión: efecto de presión de 18 horas después de 6 horas de infusión de
P J Blankestijn1, A J Man in't Veld, J Tulen
1Department of Internal Medicine I, Erasmus University Rotterdam, The Netherlands.
Lancet (London, England)
|December 17, 1988
Resumen
Este estudio encontró que una infusión de adrenalina de 6 horas causó un aumento retrasado de la presión arterial que duró hasta 18 horas. Estos hallazgos apoyan el vínculo entre la adrenalina y la hipertensión en humanos.
Área de la Ciencia:
- Fisiología cardiovascular fisiología cardiovascular.
- Endocrinología Endocrinología.
Sus antecedentes:
- La relación entre las hormonas del estrés y la hipertensión es un área importante de investigación.
- La adrenalina (epinefrina) y la noradrenalina (norepinefrina) son catecolaminas clave involucradas en la respuesta al estrés.
Objetivo del estudio:
- Para investigar los efectos hemodinámicos prolongados de las infusiones de adrenalina y noradrenalina en humanos sanos.
- Examinar la validez de la hipótesis de la hipertensión por adrenalina.
Principales métodos:
- Un estudio doble ciego y cruzado que involucró a diez voluntarios sanos.
- Se administraron infusiones de adrenalina (15 ng / kg / min), noradrenalina (30 ng / kg / min) o solución de dextrosa durante 6 horas.
- La monitorización ambulatoria intraarterial rastreó los efectos hemodinámicos durante 18 horas después de la infusión.
Principales resultados:
- La adrenalina, pero no la noradrenalina, indujo un efecto presor retardado y sostenido.
- La presión arterial sistólica y diastólica se elevó significativamente después de la infusión de adrenalina en comparación con la de la dextrosa (p < 0,001).
- Los niveles elevados de adrenalina durante 6 horas resultaron en un aumento prolongado de la presión arterial.
Conclusiones:
- Las infusiones de adrenalina a nivel de estrés pueden conducir a una hipertensión retardada y prolongada.
- Estos hallazgos proporcionan pruebas sólidas que apoyan la hipótesis adrenalina-hipertensión en humanos.
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