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Un imitador microbiano intestinal que secuestra la autorreactividad diabética para suprimir la colitis

Roopa Hebbandi Nanjundappa1, Francesca Ronchi2, Jinguo Wang1

  • 1Julia McFarlane Diabetes Research Centre (JMDRC), University of Calgary, Calgary AB T2N 4N1, Canada; Department of Microbiology, Immunology, and Infectious Diseases, Snyder Institute for Chronic Diseases, University of Calgary, Calgary AB T2N 4N1, Canada.

Cell
|October 21, 2017
PubMed
Resumen

Las bacterias intestinales pueden influir en la inmunidad. Una enzima Bacteroides integrase imita un autoantígeno, reclutando células T para suprimir la inflamación intestinal a través de la imitación molecular.

Palabras clave:
Bacteroides Integrase, también conocido como BacteroidesCélulas T citotóxicasRatones libres de gérmenesEnfermedad inflamatoria del intestinoProteína relacionada con la subunidad catalítica de la glucosa 6-fosfatasa específica de los islotes (IGRP)La imitación molecular

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