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Conocimientos cinéticos sobre la entrega de sulfuro de hidrógeno desde plataformas isoméricas de sulfuro de carbonilo
Yu Zhao1, Hillary A Henthorn1, Michael D Pluth1
1Department of Chemistry and Biochemistry, Institute of Molecular Biology, Materials Science Institute, University of Oregon , Eugene, Oregon 97403, United States.
Journal of the American Chemical Society
|October 24, 2017
Resumen
Los investigadores desarrollaron nuevos donantes de sulfuro de carbonilo enjaulado (COS) que responden al peróxido de hidrógeno (H2O2) y liberan sulfuro de hidrógeno (H2S). Estos nuevos donantes de H2S ofrecen cinética de liberación ajustable para aplicaciones biológicas.
Área de la Ciencia:
- La bioquímica
- Biología Química
- Química medicinal
Sus antecedentes:
- El sulfuro de hidrógeno (H2S) es una molécula de señalización crucial con efectos biológicos protectores.
- Los donantes de H2S son herramientas vitales para estudiar las funciones de H2S en fisiología y patología.
- Las plataformas de donantes de H2S existentes requieren modificaciones para aplicaciones más amplias.
Objetivo del estudio:
- Síntesis y caracterización de nuevos compuestos de sulfuro de carbonilo enjaulado (COS) sensibles al H2O2 como donantes de H2S.
- Investigar la cinética y la modificabilidad de la liberación de H2S de estas nuevas plataformas de donantes.
- Para explorar conocimientos computacionales sobre los mecanismos de liberación de H2S.
Principales métodos:
- Síntesis de donantes isoméricos de tiocarbamato, tiocarbonato y di-tiocarbonato de COS.
- Análisis cinético de la liberación de H2S provocada por el peróxido de hidrógeno (H2O2).
- Modificación estructural de los núcleos donantes para ajustar los perfiles de liberación.
- Modelado computacional de las superficies de energía potencial para la liberación de COS/H2S.
Principales resultados:
- Preparación exitosa de una serie de donantes de COS sensibles al H2O2.
- Se ha demostrado la liberación de H2S dependiente de la dosis de H2O2 con cinética ajustable.
- Modificaciones estructurales identificadas que influyen en las tasas de liberación y la eficiencia.
- El análisis computacional proporcionó información sobre los mecanismos de liberación.
Conclusiones:
- Desarrolló una plataforma versátil de sistemas de donantes de COS/H2S receptivos.
- Estableció una base para el diseño de herramientas avanzadas de entrega de H2S.
- Destacó el potencial de estos donantes para la investigación biológica y el desarrollo terapéutico.
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