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Comparative Lesions Analysis Through a Targeted Sequencing Approach
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Patrones universales de selección en el cáncer y los tejidos somáticos

Iñigo Martincorena1, Keiran M Raine1, Moritz Gerstung2

  • 1Wellcome Trust Sanger Institute, Hinxton CB10 1SA, Cambridgeshire, UK.

Cell
|October 24, 2017
PubMed
Resumen

Los investigadores cuantificaron la selección durante la evolución del cáncer en 7,664 tumores. Encontraron que la selección positiva es más dominante que la selección negativa, identificando numerosas mutaciones impulsoras, muchas en nuevos genes de cáncer.

Palabras clave:
el cáncerLa evoluciónLa genómicamutacionesSelección

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