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Longitudinal Evaluation of Mouse Hind Limb Bone Loss After Spinal Cord Injury using Novel, in vivo, Methodology
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Disminución desigual de la densidad ósea de la columna lumbar y del radio ultradistal en los síndromes de fractura de

R Eastell1, H W Wahner, W M O'Fallon

  • 1Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905.

The Journal of clinical investigation
|January 1, 1989
PubMed

Medimos la densidad mineral ósea (DMO) en la columna lumbar (DMO-CL) y en el radio ultradistal (DMO-RUD) en 42 mujeres postmenopáusicas sanas y en 108 mujeres postmenopáusicas con osteoporosis (55 con fractura vertebral, 34 con fractura de Colles y 19 con ambas fracturas). Mediante el análisis de la característica operativa del receptor, la DMO-CL resultó ser un mejor indicador de fractura vertebral que la DMO-RUD (P < 0,01); lo contrario ocurrió para la fractura de Colles (P < 0,01). Aunque la DMO-RUD y la DMO-CL fueron menores en cada uno de los tres grupos con fractura que en los controles (P < 0,01), el patrón de pérdida ósea fue diferente (P < 0,001, análisis de varianza): en la fractura vertebral, la DMO-CL disminuyó relativamente más que la DMO-RUD; en la fractura de Colles, la DMO-RUD disminuyó relativamente más que la DMO-CL; y en el caso de ambas fracturas, las disminuciones de la DMO-CL y la DMO-RUD fueron similares. Concluimos que ambos tipos de fractura son causados por una pérdida ósea excesiva, pero la diferencia en la pérdida ósea entre los dos sitios es un factor determinante para establecer cuál de ellos se fracturará.

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