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Acoplamientos cruzados enantiospecíficos e iterativos Suzuki-Miyaura

Jason P G Rygus¹, Cathleen M Crudden^1,2

¹Department of Chemistry, Queen's University , Chernoff Hall, Kingston, Ontario K7L 3N6, Canada.

Journal of the American Chemical Society

|November 18, 2017

Resumen

La reacción de acoplamiento cruzado Suzuki-Miyaura permite la creación de enlaces de carbono-carbono estereoquímicos. Esta perspectiva revisa los métodos para sintetizar moléculas enriquecidas con enantio utilizando esta poderosa reacción.

Área de la Ciencia:

Química orgánica
Química sintética

Sus antecedentes:

La reacción Suzuki-Miyaura es una piedra angular para la formación de enlaces carbono-carbono.
Su aplicación en la creación de enlaces sp2-sp3 con una estereoquímica definida es un área de investigación en crecimiento.

Objetivo del estudio:

Proporcionar una visión general de la síntesis de moléculas enriquecidas con enantio utilizando la reacción Suzuki-Miyaura.
Destacar los avances en las metodologías estereoselectivas y quimioselectivas de acoplamiento cruzado.

Principales métodos:

Utilizando compuestos de organoboron enriquecidos enantioméricamente en reacciones de acoplamiento estereospecíficas.
Desarrollo de reacciones enantioconvergentes y selectivas de grupo Suzuki-Miyaura.
Explorando estrategias iterativas de acoplamiento cruzado para la síntesis de moléculas complejas.

Principales resultados:

Demostración de métodos eficaces para la construcción de enlaces estereodefinidos sp2-sp3.
Avances en el control de la estereoquímica durante el acoplamiento cruzado.
Progreso en el logro de una alta quimioselectividad en secuencias de acoplamiento iterativo.

Conclusiones:

La reacción Suzuki-Miyaura ofrece estrategias versátiles para acceder a moléculas enriquecidas con enantio.
El desarrollo continuo promete aplicaciones más amplias en la síntesis compleja y el descubrimiento de fármacos.

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