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El disulfiram, un fármaco para el abuso del alcohol, ataca el cáncer a través del adaptador de segregación de p97
Zdenek Skrott1, Martin Mistrik1, Klaus Kaae Andersen2
1Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
Nature
|December 7, 2017
Resumen
La reutilización del disulfiram, un fármaco antialcohólico, es prometedora para el tratamiento del cáncer. El uso continuo en pacientes se correlacionó con un menor riesgo de muerte por cáncer, identificando un metabolito clave y su objetivo molecular.
Área de la Ciencia:
- En el campo de la oncología
- Farmacología
- Biología molecular
Sus antecedentes:
- El aumento de la incidencia del cáncer y la resistencia a los medicamentos requieren nuevas estrategias terapéuticas.
- La reutilización de medicamentos ofrece un enfoque viable para descubrir nuevos tratamientos contra el cáncer.
- El disulfiram (Antabuse), un medicamento para la aversión al alcohol, ha demostrado una actividad anticancerígena preclínica.
Objetivo del estudio:
- Investigar la eficacia de la reutilización del disulfiram para el tratamiento del cáncer.
- Identificar el metabolito activo del disulfiram responsable de sus efectos anticancerígenos.
- Para aclarar los mecanismos moleculares subyacentes a la actividad anticancerígena del disulfiram.
Principales métodos:
- Estudio epidemiológico nacional que analiza el consumo de drogas por parte de los pacientes y la mortalidad por cáncer.
- Análisis metabólico para identificar el compuesto activo del disulfiram.
- Pruebas funcionales y biofísicas para determinar objetivos moleculares.
Principales resultados:
- El uso continuo de disulfiram se asoció con un riesgo reducido de muerte relacionada con el cáncer.
- El complejo ditiocarb- cobre fue identificado como el metabolito anticancerígeno del disulfiram.
- El disulfiram se dirige a NPL4, un adaptador de segregación de p97 (VCP), crucial para la regulación de las proteínas celulares.
Conclusiones:
- Disulfiram es un prometedor fármaco reutilizado para el tratamiento del cáncer.
- El complejo ditiocarb- cobre media los efectos anticancerígenos del disulfiram.
- Dirigirse a NPL4 ofrece una nueva vía para el desarrollo de tratamientos contra el cáncer.
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