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Sobre el diseño de la terapia combinada contra el cáncer

  • 0Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Bethesda, MD, USA; Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Cell +

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16 de diciembre de 2017

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16 de diciembre de 2017

Ver abstracta en PubMed

Resumen

Este resumen es generado por máquina.

La terapia combinada contra el cáncer muestra una sinergia clínica limitada. Los estudios sugieren que incluso los tratamientos exitosos a menudo funcionan a través de los efectos individuales de los medicamentos, no de las interacciones combinadas, desafiando los enfoques actuales para el desarrollo de medicamentos contra el cáncer.

Área De La Ciencia

  • En el campo de la oncología
  • Farmacología
  • Medicina traslacional

Sus Antecedentes

  • La terapia combinada es estándar para el tratamiento de tumores malignos en humanos.
  • Se buscan interacciones farmacológicas sinérgicas para mejorar la eficacia del tratamiento.

Objetivo Del Estudio

  • Evaluar la traslación clínica de las interacciones sinérgicas de fármacos contra el cáncer observadas in vitro.
  • Determinar si el éxito de la terapia combinada se debe a la sinergia o a la acción independiente del fármaco.

Principales Métodos

  • Análisis de los datos de cultivos celulares para las interacciones farmacológicas sinérgicas.
  • Revisión de los resultados obtenidos en modelos de ratón y ensayos clínicos en humanos de terapias combinadas.

Principales Resultados

  • Las interacciones farmacológicas sinérgicas in vitro rara vez se traducen en eficacia clínica.
  • El éxito de las terapias combinadas se explica a menudo por los efectos aditivos de los fármacos individuales.
  • Los resultados clínicos no apoyan consistentemente los hallazgos de sinergia in vitro.

Conclusiones

  • La relevancia clínica de las interacciones sinérgicas de fármacos contra el cáncer in vitro es cuestionable.
  • Las actividades farmacológicas independientes son una explicación más probable del éxito de las terapias combinadas.
  • Se justifica repensar los modelos preclínicos y el análisis de ensayos clínicos para los tratamientos combinados contra el cáncer.

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