Una función metabólica de las fusiones del gen FGFR3-TACC3 en el cáncer
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Ver abstracta en PubMed
Resumen
Este resumen es generado por máquina.Las fusiones de genes FGFR3-TACC3 (F3-T3) impulsan el cáncer mediante la activación de la respiración mitocondrial. Dirigirse a esta vía metabólica ofrece una nueva estrategia terapéutica para los tumores F3-T3 positivos.
Área De La Ciencia
- En el campo de la oncología
- Biología molecular
- Metabolismo del cáncer
Sus Antecedentes
- Las translocaciones cromosómicas que crean fusiones de genes oncogénicos son objetivos clave en la terapia del cáncer.
- Las fusiones FGFR3-TACC3 (F3-T3) son factores oncogénicos que se encuentran en varios tipos de cáncer, incluido el glioblastoma.
- Las vías de señalización aguas abajo de las fusiones F3-T3 siguen siendo en gran medida desconocidas.
Objetivo Del Estudio
- Para aclarar las vías de señalización oncogénicas activadas por las fusiones F3-T3.
- Investigar el papel de la función mitocondrial en la tumorigénesis impulsada por F3-T3.
- Identificar las posibles vulnerabilidades terapéuticas en los cánceres F3-T3 positivos.
Principales Métodos
- Perfiles de transcripción de tumores humanos con fusiones F3-T3.
- Análisis de la función mitocondrial y el metabolismo oxidativo.
- Investigación del eje de señalización F3-T3-PIN4 y sus efectos posteriores.
Principales Resultados
- Las fusiones F3-T3 están asociadas con subgrupos de transcripción caracterizados por funciones mitocondriales activadas.
- F3-T3 activa la fosforilación oxidativa y la biogénesis mitocondrial, confiriendo sensibilidad a los inhibidores metabólicos.
- El eje F3-T3-PIN4 promueve la biogénesis del peroxisoma y la síntesis de proteínas, convergiendo en PGC1α a través de especies reactivas de oxígeno.
Conclusiones
- Los tumores F3-T3 positivos exhiben una fuerte dependencia de la respiración mitocondrial para el crecimiento.
- La activación del metabolismo mitocondrial mediada por F3-T3 representa una oportunidad terapéutica significativa.
- Comprender el circuito metabólico de las fusiones F3-T3 proporciona información sobre el desarrollo y el tratamiento del cáncer.
Contact us Si estos videos no son relevantes.
Contact us Si estos videos no son relevantes.
Videos de Conceptos Relacionados
The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Overview
Metabolism represents all of the chemical activity in a cell, including reactions that build molecules (anabolism) and those that break molecules down (catabolism). Anabolic reactions require energy, whereas catabolic reactions provide it. Thus, metabolism describes how cells transform energy through a variety of chemical reactions, which are often made more efficient with the help of enzymes.
Metabolism Is the Sum of All of the Chemical Reactions That Take Place in an Organism
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...