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Una visión integrada del inmunometabolismo
Yun Sok Lee1, Joshua Wollam2, Jerrold M Olefsky2
1Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Korea.
Cell
|January 13, 2018
Resumen
La obesidad causa inflamación en los tejidos metabólicos, afectando la resistencia a la insulina y la diabetes tipo 2. Comprender este inmunometabolismo es clave para desarrollar nuevas terapias para mejorar la homeostasis de la glucosa.
Área de la Ciencia:
- Metabolismo inmunológico
- Endocrinología
- Investigación sobre la obesidad
Sus antecedentes:
- La epidemia mundial de obesidad es el principal impulsor de la resistencia a la insulina y la diabetes tipo 2.
- La inflamación crónica en los tejidos metabólicos es una característica de la obesidad.
- Los avances en el inmunometabolismo iluminan los vínculos entre la inmunidad y la salud metabólica.
Objetivo del estudio:
- Revisar el conocimiento actual de la inflamación relacionada con la obesidad en los tejidos metabólicos.
- Examinar cómo la inflamación afecta la sensibilidad a la insulina, la secreción, la ingesta de alimentos y la homeostasis de la glucosa.
- Explorar la comunicación entre y dentro de los órganos en la desregulación metabólica.
Principales métodos:
- Revisión de la literatura sobre la investigación del inmunometabolismo y la obesidad.
- Análisis de las vías inflamatorias en los tejidos metabólicos.
- Síntesis de los hallazgos sobre la interconexión celular y entre órganos.
Principales resultados:
- La inflamación inducida por la obesidad afecta negativamente la sensibilidad y la secreción de insulina.
- Los cambios inflamatorios contribuyen al deterioro de la homeostasis de la glucosa y a la alteración de la ingesta de alimentos.
- La interconexión celular compleja dentro y entre los órganos exacerba la disfunción metabólica.
Conclusiones:
- Comprender la inflamación relacionada con la obesidad es crucial para la salud metabólica.
- Dirigirse a las vías inflamatorias tiene potencial terapéutico para la diabetes y los trastornos metabólicos.
- Las investigaciones adicionales sobre la comunicación entre órganos pueden guiar los estudios traslacionales.
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