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Eficiencia de alta carga de fármaco y carga sub-cuantitativa de las micelas poliméricas impulsadas por las

Shixian Lv^1,2, Yuchen Wu¹, Kaimin Cai²

¹Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University , Suzhou 215123, China.

Journal of the American Chemical Society

|January 16, 2018

Resumen

Los investigadores desarrollaron micelas poliméricas avanzadas para mejorar la administración de medicamentos. Este nuevo método logra una carga de fármaco ultra alta y una liberación dirigida de células cancerosas, mejorando la eficacia y reduciendo la toxicidad.

Área de la Ciencia:

Ciencia de los biomateriales
Nanotecnología
Sistemas de administración de fármacos

Sus antecedentes:

Las micelas poliméricas son cruciales para la administración hidrofóbica de fármacos, pero se enfrentan a desafíos en la carga de fármacos, la uniformidad, la estabilidad y la liberación.
Los métodos existentes a menudo tienen dificultades para lograr una alta eficiencia de encapsulación de fármacos y una liberación controlada.

Objetivo del estudio:

Desarrollar una nueva estrategia para la preparación de micelas poliméricas con una capacidad de carga de fármacos muy alta.
Diseñar micelas para mejorar la estabilidad coloidal, el tamaño uniforme y la liberación de fármacos dirigidos en las células cancerosas.

Principales métodos:

Síntesis de un copolímero anfifílico con unidades colgantes de ácido fenilborónico.
Utilizando las interacciones de coordinación entre polímeros y fármacos (donante-aceptor) para la encapsulación de fármacos.
Caracterización de las propiedades de la micela, incluida la carga de fármacos, el tamaño y la estabilidad.
Evaluación de la cinética de liberación de fármacos en respuesta a las especies reactivas de oxígeno (ROS).

Principales resultados:

Se alcanzó una carga de fármaco ultra alta (aproximadamente el 50%) y una eficiencia de carga casi cuantitativa (> 95%) para la doxorubicina.
Las micelas formuladas mostraron un tamaño uniforme y una excelente estabilidad coloidal.
Se ha demostrado la liberación efectiva y selectiva del fármaco provocada por altos niveles de ROS en las células cancerosas.
Mostró potencial para su aplicación con otros fármacos donantes de electrones como la epirubicina y el irinotecán.

Conclusiones:

La estrategia de coordinación entre polímeros y fármacos desarrollada ofrece un método simple y robusto para una alta carga de fármacos en micelas poliméricas.
Las micelas modificadas mejoran la eficacia anticancerígena a través de la administración de fármacos dirigidos y reducen la toxicidad sistémica.
Esta plataforma es muy prometedora para mejorar los resultados terapéuticos de los fármacos contra el cáncer hidrofóbicos.

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