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Updated: Feb 15, 2026

Using CRISPR/Cas9 Gene Editing to Investigate the Oncogenic Activity of Mutant Calreticulin in Cytokine Dependent Hematopoietic Cells
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Impactos de la dimerización de KRAS en la sensibilidad al inhibidor de MEK y en la actividad oncogénica del mutante

Chiara Ambrogio1, Jens Köhler1, Zhi-Wei Zhou2

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Cell
|January 17, 2018
PubMed
Resumen

El KRAS de tipo salvaje inhibe el crecimiento tumoral mediante la formación de dímeros con KRAS mutante, lo que confiere resistencia al inhibidor MEK en el cáncer de pulmón. La interrupción de la dimerización KRAS puede ofrecer una nueva estrategia terapéutica para los cánceres con mutantes KRAS.

Palabras clave:
El oncogén KRASVía MAPKInhibidores de la MEKdesequilibrio alélicoDimizaciónResistencia a las drogasel adenocarcinoma pulmonarAlelo de tipo salvaje

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