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El surgimiento de las culturas tridimensionales del cerebro humano
11Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California, USA.
Nature
|January 25, 2018
Resumen
Las células madre pluripotentes se autoorganizan en organoides cerebrales tridimensionales para modelar el desarrollo del cerebro humano y los trastornos neuropsiquiátricos. Este enfoque ofrece información sobre las características únicas del cerebro humano y los mecanismos de la enfermedad.
Área de la Ciencia:
- La neurociencia
- Biología del desarrollo
- Investigación con células madre
Sus antecedentes:
- Las células madre pluripotentes pueden autoorganizarse en organoides cerebrales tridimensionales (3D) in vitro.
- Estos organoides imitan aspectos del desarrollo y la función del cerebro humano.
- Los cultivos cerebrales 3D derivados de pacientes pueden modelar interacciones celulares complejas.
Objetivo del estudio:
- Para discutir el uso de cultivos cerebrales 3D para comprender el desarrollo del cerebro humano.
- Explorar ideas sobre los trastornos neuropsiquiátricos utilizando estos modelos.
- Para considerar los desafíos en el estudio de cultivos cerebrales 3D derivados de pacientes.
Principales métodos:
- Derivar cultivos cerebrales 3D específicos de la región de los individuos.
- El ensamblaje de estas culturas en ensamblados cerebrales humanos.
- Utilizando organoides y órganos esferoides para recapitular el desarrollo del cerebro.
Principales resultados:
- Los cultivos cerebrales en 3D recapitulan aspectos clave del desarrollo del cerebro humano.
- Los ensambloides generan interacciones y circuitos complejos entre células.
- Los modelos derivados de los pacientes ofrecen una plataforma para estudiar las características individuales del cerebro.
Conclusiones:
- Los cultivos y ensamblados cerebrales 3D son herramientas poderosas para estudiar el cerebro humano.
- Este enfoque proporciona información sobre las características únicas del cerebro humano y los trastornos neuropsiquiátricos.
- Se necesita un mayor desarrollo para mejorar los métodos de sondeo y manipulación de estos cultivos.
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