Video Experimental Relacionado
Updated: Feb 14, 2026
15:43
Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts
Published on: October 25, 2011
24.1K
Un subconjunto de fibroblastos asociados al cáncer determina la resistencia al tratamiento
Joerg Huelsken1, Douglas Hanahan2
1Laboratory of Tumor Heterogeneity and Stemness in Cancer, ISREC (Swiss Institute for Experimental Cancer Research), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne CH-1015, Switzerland.
Cell
|February 10, 2018
Resumen
Los investigadores identificaron un nuevo subconjunto de fibroblastos asociados con el cáncer que promueve el crecimiento del tumor y la quimiorresistencia. Este subconjunto es impulsado por una nueva vía de señalización, que ofrece nuevos objetivos terapéuticos para el tratamiento del cáncer.
Área de la Ciencia:
- En el campo de la oncología
- Biología del cáncer
- El microambiente del tumor
Sus antecedentes:
- Las células fibroblásticas en el microambiente tumoral exhiben heterogeneidad funcional.
- La identificación de estados fibroblásticos distintos es un reto debido a la falta de marcadores definitivos.
Objetivo del estudio:
- Caracterizar un nuevo subconjunto de fibroblastos pro-tumorígenos asociados al cáncer.
- Para aclarar la vía de señalización que impulsa este subconjunto de fibroblastos y su papel en la quimiorresistencia.
Principales métodos:
- Utilizó técnicas avanzadas de análisis de una sola célula.
- Las vías de señalización investigadas en los fibroblastos asociados al cáncer.
- Se evaluó el impacto del subconjunto de fibroblastos identificado en el crecimiento tumoral y la respuesta al fármaco.
Principales resultados:
- Se identificó un nuevo subconjunto de fibroblastos asociados al cáncer (CAF).
- Este subconjunto de CAF es pro-tumorigénico y media la quimiorresistencia.
- Se encontró una nueva vía de señalización para definir e impulsar este subconjunto específico de CAF.
Conclusiones:
- El estudio define un nuevo subconjunto de fibroblastos asociados al cáncer crucial para la progresión tumoral.
- El papel de este subconjunto en la quimiorresistencia lo destaca como un objetivo terapéutico potencial.
- Comprender esta nueva vía podría conducir a estrategias para superar la resistencia al tratamiento.
Más Videos Relacionados
Videos de Conceptos Relacionados
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
02:56Treatment Resistant Cancers
3.8K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
01:09Introduction to Fibroblasts
4.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
4.0K
01:22Resistivity
4.6K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
01:19Resistance
6.1K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.1K