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Riesgo de demencia en adultos con enfermedad cardíaca congénita: estudio de cohorte basado en la población
Carina N Bagge1, Victor W Henderson2,3, Henning B Laursen2
1Departments of Clinical Epidemiology (C.N.B., V.W.H., H.B.L., K.A., M.O., N.L.M.) c.n.bagge@gmail.com.
Circulation
|February 15, 2018
Resumen
Los adultos con enfermedad cardíaca congénita (CHD) tienen un riesgo 60% mayor de demencia. Este riesgo es particularmente elevado para la demencia de aparición temprana, lo que pone de relieve la necesidad crítica de más investigación y estrategias preventivas.
Área de la Ciencia:
- Cardiología
- Neurología
- Salud pública
Sus antecedentes:
- Las tasas de supervivencia de la enfermedad cardíaca congénita (CHD) a la edad adulta han aumentado.
- La enfermedad coronaria está relacionada con los factores de riesgo de demencia.
- El riesgo de demencia en adultos con enfermedad coronaria requiere investigación.
Objetivo del estudio:
- Comparar el riesgo de demencia en adultos con ECC con la población general.
- Identificar los factores de riesgo específicos y los datos demográficos asociados con la demencia en pacientes con ECC.
Principales métodos:
- Un estudio de cohorte utilizando registros médicos daneses.
- Inclusión de 10.632 adultos diagnosticados con enfermedad coronaria entre 1963 y 2012.
- Cohorte correspondiente de la población general para la comparación, con seguimiento hasta 2012.
Principales resultados:
- Los adultos con enfermedad coronaria mostraron un riesgo general de demencia 1,6 veces mayor.
- La enfermedad coronaria grave se correlacionó con un riesgo de demencia 2,0 veces mayor.
- El riesgo de demencia de inicio temprano fue 2,6 veces mayor en el grupo de EC.
Conclusiones:
- La enfermedad cardíaca congénita está asociada con un mayor riesgo de demencia.
- La demencia de inicio temprano es una preocupación significativa para los adultos con ECC.
- Se justifica una mayor investigación sobre el riesgo de demencia dentro de la población de EC.
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