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The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
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The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
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The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
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The spinal cord resides within the protective confines of the vertebral column. It is the main pathway for information traveling between the brain and the body. It plays a fundamental role in nearly all bodily functions, from simple reflexes to complex motor movements. The spinal cord begins at the medulla oblongata at the base of the brainstem and extends downward, terminating at the conus medullaris near the first and second lumbar vertebrae. The spinal cord's length in adults is...
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The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
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A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
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Perfiles unicelulares del cerebro y la médula espinal del ratón en desarrollo con código de barras dividido

Alexander B Rosenberg1, Charles M Roco2, Richard A Muscat3

  • 1Department of Electrical Engineering, University of Washington, Seattle, WA, USA. alex.b.rosenberg@gmail.com gseelig@uw.edu.

Science (New York, N.Y.)
|March 17, 2018
PubMed
Resumen
Este resumen es generado por máquina.

Desarrollamos la secuenciación del transcriptoma basada en la ligadura de grupo dividido (SPLiT-seq) para la secuenciación escalable de ARN de una sola célula. Este método identificó más de 100 tipos de células en el cerebro y la médula espinal de ratones en desarrollo.

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Área de la Ciencia:

  • Biología molecular
  • La genómica
  • La neurociencia

Sus antecedentes:

  • La secuenciación de ARN de una sola célula (scRNA-seq) es crucial para comprender los sistemas biológicos complejos.
  • Los métodos existentes de scRNA-seq se enfrentan a desafíos en cuanto a escalabilidad y compatibilidad con muestras fijas.

Objetivo del estudio:

  • Desarrollar un método scRNA-seq escalable y versátil para el perfil celular integral.
  • Para analizar los transcriptomas del sistema nervioso central en desarrollo del ratón a resolución de una sola célula.

Principales métodos:

  • Se desarrolló la secuenciación del transcriptoma basada en la ligadura de grupo dividido (SPLiT-seq) utilizando códigos de barras combinatorios.
  • Se aplicó SPLiT-seq para analizar 156.049 transcriptomas de un solo núcleo de cerebros y médula espinal de ratones postnatales.
  • Se utilizó el análisis del pseudo-tiempo para investigar las trayectorias de desarrollo.

Principales resultados:

  • Identificó más de 100 tipos de células distintas basadas en patrones de expresión génica.
  • Tipos celulares caracterizados por función, especificidad regional y etapa de diferenciación.
  • Reveló programas de transcripción que impulsan cuatro líneas principales de desarrollo en el SNC murino posnatal temprano.

Conclusiones:

  • SPLiT-seq permite un perfil transcriptómico de una sola célula escalable y eficiente.
  • Proporciona una instantánea detallada del desarrollo temprano del sistema nervioso central postnatal.
  • Ofrece un método para el análisis integral de otros sistemas multicelulares complejos.