Video Experimental Relacionado
Updated: Feb 12, 2026
08:53
In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
Published on: September 16, 2019
9.6K
El microbioma en la inmunoterapia del cáncer: herramientas de diagnóstico y estrategias terapéuticas
Laurence Zitvogel1,2,3,4, Yuting Ma5,6, Didier Raoult7
1Gustave Roussy Cancer Campus (GRCC), Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France. laurence.zitvogel@gustaveroussy.fr tgajewsk@medicine.bsd.uchicago.edu.
Science (New York, N.Y.)
|March 24, 2018
Resumen
El microbioma humano influye en el desarrollo del cáncer y la respuesta al tratamiento. La modulación del microbioma intestinal ofrece potencial para mejorar las terapias contra el cáncer y las estrategias de medicina de precisión.
Área de la Ciencia:
- Investigación del microbioma
- Biología del cáncer
- La inmunoterapia
Sus antecedentes:
- El microbioma humano, que abarca todos los factores microbianos, juega un papel crítico en la salud y la enfermedad.
- La interacción entre el huésped y los factores microbianos tiene un impacto significativo en el inicio, la progresión y las respuestas terapéuticas del cáncer.
Objetivo del estudio:
- Para resaltar el papel del microbioma en el cáncer.
- Discutir la influencia de los factores microbianos en la eficacia del tratamiento del cáncer.
- Explorar las direcciones futuras en las terapias contra el cáncer basadas en el microbioma.
Principales métodos:
- Revisión de la literatura existente sobre las interacciones huésped-microbioma en el cáncer.
- Análisis del impacto microbiano en la quimioterapia y la inmunoterapia.
- Discusión de la interacción del sistema inmunológico con los ecosistemas microbianos.
Principales resultados:
- Las especies microbianas específicas pueden alterar la farmacodinámica de la quimioterapia.
- El microbioma huésped afecta el sistema inmunológico, influyendo en los resultados de los pacientes con cáncer.
- El uso de antibióticos puede reducir la eficacia de la inmunoterapia, mientras que ciertos microbios intestinales la mejoran.
Conclusiones:
- El microbioma es un regulador clave de la progresión del cáncer y la respuesta al tratamiento.
- Dirigirse al microbioma es prometedor para mejorar las terapias contra el cáncer.
- Los enfoques futuros de la medicina de precisión probablemente involucrarán la corrección de defectos del microbioma para mejorar los resultados terapéuticos.
Más Videos Relacionados
Videos de Conceptos Relacionados
01:27Tumor Immunotherapy
2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
01:13Therapeutic Index
6.9K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.9K
01:30Therapeutic Communication
8.7K
Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
8.7K
01:52Persuasion Strategies
43.5K
Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
43.5K
01:26Cholinergic Antagonists: Therapeutic Uses
1.5K
Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.5K
01:29Microorganisms in Medicine and Therapeutics
1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K