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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Esclerosis múltiple

Alan J Thompson1, Sergio E Baranzini2, Jeroen Geurts3

  • 1Queen Square MS Centre, UCL Institute of Neurology, London, UK; NIHR University College London Hospitals Biomedical Research Centre, London, UK.

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|March 27, 2018
PubMed
Resumen
Este resumen es generado por máquina.

Comprender la esclerosis múltiple (EM) implica factores genéticos y ambientales como la falta de vitamina D. El diagnóstico temprano y los planes de tratamiento personalizados mejoran la calidad de vida de los pacientes con EM.

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Área de la Ciencia:

  • Neurología
  • Inmunología

Sus antecedentes:

  • La esclerosis múltiple (EM) es una condición neurológica compleja con discapacidad significativa.
  • Los factores genéticos y ambientales, incluida la falta de vitamina D, el tabaquismo y la obesidad, están implicados en la patogénesis de la EM.

Objetivo del estudio:

  • Proporcionar una visión general de la comprensión y el tratamiento actuales de la esclerosis múltiple.
  • Para resaltar los avances en el diagnóstico, el tratamiento y las estrategias de atención al paciente para la EM.

Principales métodos:

  • Revisión de la literatura actual sobre la etiología, el diagnóstico y el tratamiento de la esclerosis múltiple.
  • Incorporación de criterios de diagnóstico que incluyen neuroimagen y análisis del líquido cefalorraquídeo.
  • Consideración de las directrices terapéuticas para la EM recurrente-remitente.

Principales resultados:

  • El diagnóstico precoz es facilitado por criterios establecidos para los síndromes clínicamente aislados.
  • Hay una amplia gama de terapias orales e infusas disponibles para la EM recidivante-remitente.
  • Los enfoques de la medicina personalizada están respaldados por las directrices clínicas.

Conclusiones:

  • Los programas integrales de manejo que se centran en el bienestar y el manejo de la comorbilidad son cruciales para mejorar la calidad de vida de los pacientes con EM.
  • La investigación futura debe centrarse en la neuroprotección y la remielinización para abordar las formas progresivas de EM.
  • Es esencial optimizar la selección del tratamiento en función de los perfiles de eficacia y efectos secundarios.