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Los heteropolímeros aleatorios conservan la función de las proteínas en entornos extraños

Brian Panganiban¹, Baofu Qiao², Tao Jiang¹

¹Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA 94720, USA.

Science (New York, N.Y.)

|March 29, 2018

Resumen

Este resumen es generado por máquina.

Los científicos crearon nuevos polímeros sintéticos que estabilizan y solubilizan las proteínas en condiciones no nativas. Este avance permite el desarrollo de biomateriales avanzados, como plásticos que contienen enzimas para la biorremediación de toxinas.

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Área de la Ciencia:

Ciencia de los biomateriales
Química de los polímeros
Biotecnología

Sus antecedentes:

La incorporación de proteínas activas en polímeros sintéticos ofrece el potencial para nuevos biomateriales.
Las proteínas normalmente no funcionan bajo condiciones estándar de procesamiento de polímeros.
Imitar las proteínas intrínsecamente desordenadas es clave para superar este desafío.

Objetivo del estudio:

Diseñar heteropolímeros sintéticos capaces de solubilizar y estabilizar las proteínas en entornos no nativos.
Crear una nueva estrategia para la interfaz de sistemas biológicos con materiales sintéticos para aplicaciones basadas en proteínas.

Principales métodos:

Análisis de las tendencias de la secuencia de proteínas y los patrones químicos de la superficie.
Diseño de heteropolímeros aleatorios de cuatro monómeros con una composición optimizada y una distribución estadística de monómeros.
Aplicación de heteropolímeros en la síntesis libre de células de proteínas de membrana y plásticos que contienen enzimas.

Principales resultados:

Desarrolló heteropolímeros que imitan las proteínas intrínsecamente desordenadas, lo que permite la estabilización de las proteínas en condiciones no nativas.
Logró el plegamiento de proteínas adecuado para el transporte en proteínas de membrana sintetizadas libres de células.
Se ha demostrado el éxito de la biorremediación de toxinas utilizando plásticos que contienen enzimas.

Conclusiones:

El control de la distribución estadística de monómeros en heteropolímeros es una estrategia viable para la estabilización de proteínas.
Este enfoque permite la creación de biomateriales funcionales basados en proteínas para diversas aplicaciones.
Los hallazgos abren nuevas vías para la interfaz de funciones biológicas con materiales sintéticos.