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Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

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GDV1 induce el compromiso sexual de los parásitos de la malaria al antagonizar el silenciamiento del gen dependiente

Michael Filarsky^1,2, Sabine A Fraschka³, Igor Niederwieser^1,2

¹Swiss Tropical and Public Health Institute, 4051 Basel, Switzerland.

Science (New York, N.Y.)

|March 29, 2018

Resumen

Los investigadores descubrieron GDV1, una proteína que desencadena el desarrollo sexual del parásito de la malaria al contrarrestar el silenciamiento genético. Este hallazgo es crucial para comprender la transmisión de la malaria y desarrollar nuevas estrategias de control.

Área de la Ciencia:

Parasitología molecular
La genética
Transmisión de enfermedades

Sus antecedentes:

La malaria surge de los parásitos Plasmodium, cuyos gametocitos son esenciales para la transmisión de los mosquitos.
El compromiso sexual en Plasmodium está regulado por AP2-G, un regulador de la transcripción.
El silenciamiento mediado por HP1 del gen ap2-g inhibe la conversión sexual en parásitos proliferantes.

Objetivo del estudio:

Para identificar los activadores de la actividad sexual en los parásitos Plasmodium.
Para aclarar el mecanismo molecular por el cual Plasmodium falciparum inicia el desarrollo de gametocitos.

Principales métodos:

Análisis de la expresión génica
Inmunoprecipitación de la cromatina
Estudios de ARN antisenso
Estudios de localización de proteínas

Principales resultados:

GDV1 identificado como un activador de la actividad sexual.
GDV1 se dirige a la heterocromatina, induciendo el desalojo de HP1 y la despresión de ap2-g.
La expresión de GDV1 está regulada por señales ambientales y un ARN antisentido gdv1.

Conclusiones:

GDV1 actúa como una proteína efector clave que induce la diferenciación sexual en Plasmodium.
GDV1 antagoniza el silenciamiento de genes dependientes de HP1 para promover la gametocitogénesis.
Comprender el papel del GDV1 ofrece objetivos potenciales para las intervenciones de bloqueo de la transmisión de la malaria.

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