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Trazabilidad de clones de todo el organismo mediante secuenciación de una sola célula

Anna Alemany1, Maria Florescu1, Chloé S Baron1

  • 1Oncode Institute, Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.

Nature
|March 29, 2018
PubMed
Resumen
Este resumen es generado por máquina.

ScarTrace, una nueva estrategia de secuenciación de una sola célula, rastrea simultáneamente la identidad celular y la historia clonal en el pez cebra. Este método revela cómo los progenitores embrionarios generan diversos tipos de células en los tejidos adultos, lo que ayuda a comprender el desarrollo del organismo.

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Área de la Ciencia:

  • Biología del desarrollo
  • La genómica
  • Biología celular

Sus antecedentes:

  • Comprender cómo los progenitores embrionarios limitados generan todos los tipos de células adultas es crucial para la biología del desarrollo.
  • La medición simultánea de la historia clonal y la identidad celular a resolución de una sola célula ha sido un desafío técnico significativo.
  • Los métodos existentes para rastrear la historia clonal a menudo son indirectos o carecen de resolución de una sola célula.

Objetivo del estudio:

  • Desarrollar una estrategia de secuenciación de una sola célula para la cuantificación simultánea de la historia clonal y el tipo de célula.
  • En el caso de los peces cebra adultos, se utilizará esta estrategia para trazar un mapa de los tipos de células derivadas de los progenitores.
  • Investigar el compromiso progenitor y las decisiones del destino celular durante el desarrollo y la regeneración embrionaria.

Principales métodos:

  • Desarrollo de ScarTrace, una estrategia de secuenciación de una sola célula.
  • Aplicación de ScarTrace a miles de células de varios órganos de peces cebra adultos.
  • Análisis de las relaciones clonales y clasificación por tipo celular utilizando datos transcriptómicos.

Principales resultados:

  • Se han identificado progenitores embrionarios multipotentes que generan todas las células hematopoyéticas en la médula renal del pez cebra.
  • Se ha demostrado la generación de tipos de células progenitoras específicas en los ojos y el cerebro, y se ha estudiado el compromiso de la lateralidad ocular.
  • Reveló progenitores compartidos para las células epidérmicas y mesenquimales en las aletas caudales e identificó orígenes clonales distintos para las células inmunes residentes.

Conclusiones:

  • ScarTrace permite el análisis simultáneo de alta resolución de la historia clonal y la identidad celular.
  • El estudio proporciona un mapa detallado de los tipos de células derivadas del progenitor en peces cebra adultos.
  • Este enfoque ofrece una herramienta poderosa para reconstruir el desarrollo del organismo a partir de células individuales en varios sistemas experimentales.