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Videos de Conceptos Relacionados

Mass Analyzers: Overview01:13

Mass Analyzers: Overview

1.8K
The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
1.8K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

1.6K
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
1.6K
Tumor Progression02:07

Tumor Progression

7.5K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.5K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.9K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.9K
Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

989
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
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Video Experimental Relacionado

Updated: Feb 12, 2026

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
08:00

Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal

Published on: October 11, 2019

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SnapShot: Tumores analizados por el TCGA

Amy Blum1, Peggy Wang1, Jean C Zenklusen1

  • 1Center for Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Cell
|April 7, 2018
PubMed
Resumen

El programa Atlas del Genoma del Cáncer (TCGA) ha caracterizado numerosos tipos de tumores. Esta visión general destaca los descubrimientos clave para cada tipo de cáncer de los documentos de marcadores TCGA.

Área de la Ciencia:

  • En el campo de la oncología
  • La genómica
  • Investigación del cáncer

Sus antecedentes:

  • El programa Atlas del Genoma del Cáncer (TCGA) ha generado datos genómicos completos para varios tipos de cáncer.
  • Comprender el paisaje molecular de los tumores es crucial para avanzar en el diagnóstico y tratamiento del cáncer.

Objetivo del estudio:

  • Proporcionar una lista consolidada de los tipos de tumores analizados por el programa TCGA.
  • Para resumir los descubrimientos genómicos más importantes para cada tipo de tumor caracterizado.

Principales métodos:

  • Revisión de los papeles del marcador TCGA.
  • Identificación de hallazgos clave relacionados con la genómica tumoral.

Principales resultados:

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  • Un catálogo completo de los tipos de tumores caracterizados por TCGA.
  • Resúmenes de los principales descubrimientos, incluidas las mutaciones del conductor, las alteraciones genómicas y los subtipos moleculares para cada tumor.

    • Conclusiones:

    • El programa TCGA ha avanzado significativamente en nuestra comprensión del cáncer a nivel genómico.
    • Este recurso sirve como una referencia vital para los investigadores del cáncer y los médicos.