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Updated: Feb 11, 2026

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La expresión del antígeno de la línea germinal del cáncer discrimina el resultado clínico del bloqueo de CTLA-4

Sachet A Shukla1, Pavan Bachireddy2, Bastian Schilling3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA.

Cell
|April 17, 2018
PubMed
Resumen

Una firma genética MAGE-A específica predice la resistencia al bloqueo CTLA-4 en el melanoma. Esta resistencia está relacionada con la supresión de la autofagia, lo que sugiere la inducción de la autofagia como una terapia potencial.

Palabras clave:
CTLA-4 (en inglés)Se incluyen los siguientes elementos:PD-1 y sus derivadosLa autofagiaantígeno de la línea germinal del cáncerBloqueo de los puntos de controlLa inmunogenómicainmunoterapiaIpilimumab y sus derivadosel melanoma

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