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El seguimiento de la evolución del cáncer revela rutas restringidas a las metástasis: TRACERx renal
Samra Turajlic1, Hang Xu2, Kevin Litchfield2
1Translational Cancer Therapeutics Laboratory, the Francis Crick Institute, London NW1 1AT, UK; Renal and Skin Units, the Royal Marsden Hospital NHS Foundation Trust, London SW3 6JJ, UK.
Cell
|April 17, 2018
Resumen
El carcinoma renal de células claras metastásico (CCRCC) muestra una progresión variada. La complejidad cromosómica, particularmente la pérdida de 9p, impulsa la metástasis y la mortalidad de ccRCC, lo que influye en los patrones de diseminación.
Área de la Ciencia:
- En el campo de la oncología
- La genética
- Patología
Sus antecedentes:
- El carcinoma renal de células claras (CCRCC) tiene diversos comportamientos metastásicos.
- Se carece de un estudio sistemático de los fenotipos metastásicos del ccRCC.
Objetivo del estudio:
- Para analizar los fenotipos metastásicos en el carcinoma renal de células claras.
- Identificar los factores genéticos de la metástasis y la mortalidad del CCRC.
Principales métodos:
- Análisis de 575 biopsias primarias y 335 metastásicas de CCRC de 100 pacientes.
- Examen de muestras de tumores, incluidas las biopsias post mortem.
- Correlación de la complejidad cromosómica con la competencia metastásica y la supervivencia.
Principales resultados:
- La competencia metastásica está vinculada a la complejidad cromosómica.
- La pérdida del cromosoma 9p es un evento clave que impulsa la metástasis y la mortalidad del ccRCC (p=0,0014).
- Se observaron patrones metastásicos distintos: propagación rápida en múltiples sitios de tumores monoclonales frente a la adquisición gradual en tumores heterogéneos.
Conclusiones:
- La complejidad cromosómica y las alteraciones genéticas específicas como la pérdida de 9p son críticas en la metástasis de ccRCC.
- La heterogeneidad del tumor influye en la tasa y el patrón de progresión metastásica.
- Las metástasis pancreáticas muestran divergencia temprana de clones y largos períodos de latencia.
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