Video Experimental Relacionado

Updated: Feb 11, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

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Un enfoque integrado de CRISPR a nivel genómico para funcionalizar los lncRNA en la resistencia a los medicamentos

Assaf C Bester1, Jonathan D Lee1, Alejandro Chavez2

  • 1Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Ludwig Center at Harvard, Harvard Medical School, Boston, MA, USA.

Cell
|April 21, 2018
PubMed
Resumen

Este estudio introduce una nueva plataforma de detección CRISPR (DICaS) para encontrar genes que afectan la resistencia a los medicamentos contra el cáncer. Identificó nuevos genes de ciclo celular, supervivencia y señalización, incluido el GAS6-AS2 lncRNA, que contribuye a la resistencia a la quimioterapia en la LMA.

Palabras clave:
La lucha contra el blanqueoAXL y GAS6CRISPR y sus derivadosCRISPR y sus derivadosTEM (en inglés)el cáncerLa citarabinaResistencia a las drogasLa leucemiaEn el ADN

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