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Updated: Feb 11, 2026

Retropinacol/Cross-pinacol Coupling Reactions - A Catalytic Access to 1,2-Unsymmetrical Diols
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Estereocentros cuaternarios a través de una reacción catalítica enantioconvergente SN1

Alison E Wendlandt1, Prithvi Vangal1, Eric N Jacobsen2

  • 1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Nature
|April 27, 2018
PubMed
Resumen

Este estudio introduce la catálisis asimétrica para las reacciones de sustitución nucleofílica unimolecular (SN1), lo que permite la síntesis enantioselectiva de estereocentros cuaternarios a partir de precursores racémicos. Se logra un alto control sobre la distribución del producto y la estereoselectividad utilizando un catalizador quiral y un promotor de ácido de Lewis.

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