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Los mapas sinápticos interregionales entre las células del engrama subyacen a la formación de la memoria
Jun-Hyeok Choi1, Su-Eon Sim1, Ji-Il Kim1
1School of Biological Sciences, Seoul National University, Gwanak-gu, Seoul 08826, South Korea.
Science (New York, N.Y.)
|April 28, 2018
Resumen
Los científicos descubrieron que las conexiones más fuertes entre las células cerebrales, específicamente las células engram, almacenan físicamente los recuerdos. Esta conectividad mejorada en las regiones CA1 y CA3 del cerebro se correlaciona directamente con la fuerza y la formación de la memoria.
Área de la Ciencia:
- La neurociencia
- Biología celular
- Investigación de la memoria
Sus antecedentes:
- Se teoriza que el almacenamiento de memoria involucra plasticidad sináptica dentro de las células del engrama.
- La ubicación física precisa de la codificación de la memoria dentro de estas células sigue siendo en gran medida teórica.
Objetivo del estudio:
- Para identificar el sustrato neuronal específico para el almacenamiento de la memoria.
- Para investigar los cambios sinápticos en las células del engrama durante la formación de la memoria.
Principales métodos:
- Desarrollo de la técnica dual-eGRASP (reconstitución de proteínas fluorescentes verdes a través de socios sinápticos).
- Examen de las sinapsis entre las células del engrama CA3 y CA1.
- Evaluación del condicionamiento contextual del miedo y la potenciación a largo plazo (LTP).
Principales resultados:
- Se observó un aumento en el número y el tamaño de las espinas dendríticas en las células engramáticas CA1 que recibieron información de las células engramáticas CA3.
- La conectividad mejorada entre las células de engramas se correlacionó con la fuerza de la memoria en el condicionamiento contextual del miedo.
- Las proyecciones de engramas de CA3 a CA1 ocluyeron significativamente la potenciación a largo plazo.
Conclusiones:
- La conectividad estructural y funcional mejorada entre las células del engrama es el correlato sináptico para la formación de la memoria.
- Los cambios sinápticos específicos en las células de engramas CA1 que reciben la entrada de las células de engramas CA3 son críticos para la codificación de la memoria.
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