Video Experimental Relacionado
Updated: Feb 11, 2026
10:11
Fundus Photography as a Convenient Tool to Study Microvascular Responses to Cardiovascular Disease Risk Factors in Epidemiological Studies
Published on: October 22, 2014
19.7K
Las variantes de LPA se asocian con el riesgo cardiovascular residual en pacientes que reciben estatinas
Wei-Qi Wei1, Xiaohui Li2, Qiping Feng3
1Department of Biomedical Informatics (W.-Q.W., J.D.M., J.C.D.), Vanderbilt University Medical Center, Nashville, TN.
Circulation
|April 29, 2018
Resumen
Las variaciones genéticas en el locus LPA están relacionadas con los eventos de enfermedad coronaria (CHD) en pacientes que toman estatinas. Este hallazgo es independiente de los niveles de colesterol y sugiere que el tratamiento dirigido a las lipoproteínas puede reducir el riesgo residual.
Área de la Ciencia:
- La genética
- Cardiología
- Farmacogenómica
Sus antecedentes:
- Las enfermedades coronarias siguen siendo una de las principales causas de mortalidad en todo el mundo.
- Las estatinas reducen el colesterol de lipoproteínas de baja densidad (LDL-C) y la incidencia de CHD, pero el riesgo residual persiste en algunos pacientes.
- Los factores genéticos que influyen en este riesgo cardiovascular residual durante el tratamiento con estatinas son en gran medida desconocidos.
Objetivo del estudio:
- Identificar los determinantes genéticos del riesgo cardiovascular residual en pacientes que experimentan eventos de ECC a pesar del tratamiento con estatinas.
- Investigar la asociación de las variantes genéticas dentro del locus LPA/PLG con los eventos de ECC durante el tratamiento con estatinas.
Principales métodos:
- Se realizó un estudio de asociación genómica en dos etapas (GWAS) en casos con eventos de ECC durante el tratamiento con estatinas y controles sin eventos.
- La replicación de las variantes candidatas se realizó en una cohorte independiente.
- Se utilizó un estudio de asociación de todo el fenómeno (PheWAS) para explorar otros rasgos relacionados con el locus genético más significativo.
Principales resultados:
- El metanálisis identificó 7 polimorfismos de nucleótido único (SNP) en el locus LPA/ PLG significativamente asociados con eventos de ECC durante el tratamiento con estatinas.
- La asociación más fuerte fue con SNP intrónico rs10455872 (P=2.6×10-10), que se replicó en una cohorte independiente.
- La asociación de rs10455872 con eventos de enfermedad coronaria fue independiente de la reducción de LDL-C inducida por estatinas y persistió en pacientes con LDL-C ≤70 mg/ dL.
Conclusiones:
- Las variaciones genéticas en el locus LPA están asociadas con eventos de ECC durante el tratamiento con estatinas, independientemente de la reducción de LDL-C.
- Estos hallazgos apoyan la exploración de estrategias terapéuticas dirigidas a las concentraciones de lipoproteínas circulantes para mitigar el riesgo residual de ECC en pacientes que toman estatinas.
Videos de Conceptos Relacionados
01:07Residual Plots
6.5K
A residual plot is a statistical representation of data used to analyze correlation and regression results. It helps verify the requirements for drawing specific conclusions about correlation and regression. To obtain the residual plot, first, the residual for each data value is calculated, which is simply the vertical distance between the observed and the predicted value obtained from the regression equation.
When the residual values are plotted against the variable x, it is called a residual...
When the residual values are plotted against the variable x, it is called a residual...
6.5K
01:26Residual Stresses
658
Residual stresses reside in a structure even after removing the original stress inducer. This phenomenon often arises from varied plastic deformations across different parts of a structure. Consider a rod stretched beyond its yield point. It will not regain its original length due to permanent deformation. Even after load removal, the rod does not entirely lose stress because of uneven plastic deformations, resulting in residual stresses. The computation of these stresses in structures is...
658
02:30Histone Variants at the Centromere
5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
01:15Receiver Operating Characteristic Plot
492
A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
492
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.5K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.5K
01:12Relative Risk
2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K