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Transición de micela a vesícula dirigida por la conformación de un polipéptido decorado con colesterol provocado por

Hang Liu¹, Rui Wang¹, Jing Wei¹

¹College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering , Sichuan University , Chengdu 610065 , China.

Journal of the American Chemical Society

|May 4, 2018

Resumen

Los conjuntos de polipéptidos sintéticos se transforman de micelas a vesículas en respuesta a las especies reactivas de oxígeno (ROS). Este cambio conformacional, de hoja β a hélice α, permite aplicaciones inteligentes de administración de fármacos y biosensores.

Área de la Ciencia:

Química de los polímeros
Nanotecnología
Ingeniería biomédica

Sus antecedentes:

El autoensamblaje jerárquico de polipéptidos sintéticos es crucial para las aplicaciones nanotecnológicas y biomédicas.
El control de la morfología y la función de las nanoestructuras a través de estructuras secundarias es un área poco explorada.

Objetivo del estudio:

Investigar la transformación de las micelas en vesículas de los conjuntos de copolímeros decorados con colesterol.
Explorar la correlación entre los cambios de estructura secundaria (de la hoja β a la hélice α) y las transiciones morfológicas.
Demostrar la utilidad de los conjuntos regulados por conformación para la liberación desencadenada y las interacciones celulares, particularmente en el tratamiento del cáncer.

Principales métodos:

Síntesis de copolímeros decorados con colesterol y l-cisteína.
Caracterización de las nanoestructuras autoensambladas (mícelas y vesículas).
Investigación de los cambios conformacionales en respuesta a las especies reactivas de oxígeno (ROS).
Estudios in vitro e in vivo para aplicaciones de tratamiento del cáncer.

Principales resultados:

Se observó una inusual transformación de micela a vesícula provocada por ROS.
Correlacionó la transición morfológica con un cambio conformacional de la hoja β a la hélice α.
Demostró un mecanismo de "encendido-apagado" para la liberación desencadenada y la interacción celular.
Validación de la eficacia de la estrategia in vitro e in vivo para el tratamiento del cáncer.

Conclusiones:

Los cambios en la conformación del polipéptido pueden controlar eficazmente la morfología y la función de la nanoestructura.
Los conjuntos de polipéptidos sensibles a ROS ofrecen una plataforma novedosa para la administración y el diagnóstico inteligentes de medicamentos.
Este trabajo proporciona nuevos conocimientos sobre el plegamiento de polipéptidos, el ensamblaje jerárquico y el desarrollo de plataformas biomédicas avanzadas.

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