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Updated: Feb 10, 2026

Isolation and Expansion of Human Glioblastoma Multiforme Tumor Cells Using the Neurosphere Assay

Isolation and Expansion of Human Glioblastoma Multiforme Tumor Cells Using the Neurosphere Assay

Published on: October 30, 2011

Un atlas anatómico de transcripción del glioblastoma humano

Ralph B Puchalski^1,2, Nameeta Shah^3,4, Jeremy Miller⁵

¹Allen Institute for Brain Science, Seattle, WA 98109, USA. mikeh@alleninstitute.org rbpuchalski@gmail.com nameeta.shah@gmail.com.

Science (New York, N.Y.)

|May 12, 2018

Resumen

Este estudio presenta el Atlas de Glioblastoma de Ivy, que vincula las características del tumor con los datos moleculares. Este recurso ayuda a comprender y tratar el glioblastoma multiforme agresivo (GBM).

Área de la Ciencia:

Neuro-oncología
La genómica
Biología computacional

Sus antecedentes:

El glioblastoma (GBM) es un tumor cerebral agresivo con un mal pronóstico.
Las complejas características moleculares y celulares de GBM no se comprenden bien en relación con las características histológicas de diagnóstico.

Objetivo del estudio:

Para crear un atlas transcripcional basado en la anatomía del glioblastoma humano.
Para correlacionar las características histológicas con alteraciones genómicas y patrones de expresión génica.

Principales métodos:

Desarrollo del Atlas del Glioblastoma de Ivy.
Alineación de las características histológicas con los datos genómicos y de expresión génica.
Creación de una base de datos en línea de libre acceso.

Principales resultados:

El atlas vincula con éxito características histológicas específicas a alteraciones moleculares y perfiles de expresión génica.
La información molecular se asigna a las características morfológicas clave del glioblastoma.

Conclusiones:

El Atlas de Glioblastoma de Ivy proporciona un recurso valioso para la investigación del glioblastoma.
Esta plataforma avanzará en futuras investigaciones sobre la patogénesis, el diagnóstico y el tratamiento del glioblastoma.

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