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Quimioterapia antiviral y quimioprofilaxis para el tratamiento de la enfermedad

Science (New York, N.Y.)

|March 15, 1985

Resumen

Los compuestos antivirales son efectivos para el tratamiento de infecciones virales como la gripe. La investigación futura se centra en terapias dirigidas y en abordar desafíos como la resistencia y la dosificación óptima.

Área de la Ciencia:

Virología Virología.
Enfermedades infecciosas Enfermedades infecciosas.
Farmacología Farmacología.

Sus antecedentes:

Los compuestos antivirales se utilizan para la quimioprofilaxis y la quimioterapia contra las infecciones virales humanas.
La eficacia de varios agentes antivirales está respaldada por rigurosos ensayos clínicos.
Los avances de la virología molecular permiten la identificación de objetivos específicos de virus para el desarrollo de fármacos.

Objetivo del estudio:

Revisar el estado actual de los compuestos antivirales en las infecciones humanas.
Para resaltar los desafíos y las direcciones futuras en el desarrollo de medicamentos antivirales.
Para abordar cuestiones clínicas relacionadas con el uso antiviral, similares a las de los antibióticos.

Principales métodos:

Revisión de la literatura existente sobre los compuestos antivirales.
Análisis de los avances en virología molecular para la identificación de objetivos.
Discusión de las consideraciones clínicas para la terapia antiviral.

Principales resultados:

Eficacia establecida de ciertos compuestos antivirales en ensayos controlados.
Identificación de funciones virales específicas como objetivos para nuevos fármacos antivirales.
Aparición de preguntas clínicas con respecto a la administración, la dosis, los riesgos de la profilaxis y la resistencia.

Conclusiones:

El desarrollo de medicamentos antivirales está avanzando con la virología molecular.
La aplicación clínica de los antivirales plantea preguntas análogas al uso de antibióticos.
La investigación futura debe abordar el uso óptimo y mitigar la resistencia a los compuestos antivirales.

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