Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

What is Cell Signaling?02:03

What is Cell Signaling?

131.0K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
131.0K
Cell-surface Signaling01:21

Cell-surface Signaling

54.6K
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
54.6K
What are Cells?01:07

What are Cells?

202.3K
Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
Furthermore, a living cell possesses genetic information...
202.3K
Bacterial Signaling01:30

Bacterial Signaling

40.9K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.9K
Yeast Signaling01:28

Yeast Signaling

17.3K
Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...
17.3K
Overview of Cell Signaling01:23

Overview of Cell Signaling

24.9K
Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
24.9K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Patterning human kidney organoids with synthetic Wnt-secreting organizers.

Science (New York, N.Y.)·2026
Same author

Filamin-ETV4/5 acts as mechanosensor-mechanotransducer axis that drives cell competition-mediated elimination of transformed cells.

Nature communications·2026
Same author

Multi-Tiered µDicer Enables Protein-Preserving Microdissection at 10 µm Resolution.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

DROP-CARs: Engineering Reversible, Drug-Controlled CAR T Cell Activity with a Clinically Approved Small Molecule.

Cancer research·2026
Same author

Spike-in probe-enhanced single-cell RNA-seq reveals post-infusion transcriptomic remodeling of "prime-and-kill" synNotch-CAR-T cells.

bioRxiv : the preprint server for biology·2026
Same author

Characterization of cellular wound resistance in the giant ciliate <i>Stentor coeruleus</i>.

Soft matter·2025
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
Ver todos los artículos relacionados

Video Experimental Relacionado

Updated: Feb 9, 2026

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction
07:43

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction

Published on: April 19, 2024

4.0K

Programación de estructuras multicelulares autoorganizadas con señalización celular sintética

Satoshi Toda1, Lucas R Blauch2, Sindy K Y Tang2

  • 1Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, and Center for Systems and Synthetic Biology, University of California, San Francisco, CA 94158, USA.

Science (New York, N.Y.)
|June 2, 2018
PubMed
Resumen
Este resumen es generado por máquina.

Los científicos diseñaron redes simples de comunicación célula-célula para crear tejidos auto-organizados. Estos sistemas artificiales imitan el desarrollo natural, mostrando potencial para la ingeniería de tejidos personalizados.

Más Videos Relacionados

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

24.0K
Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer
09:37

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Published on: April 27, 2020

11.7K

Videos de Experimentos Relacionados

Last Updated: Feb 9, 2026

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction
07:43

Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction

Published on: April 19, 2024

4.0K
Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells
12:44

Use of LysoTracker to Detect Programmed Cell Death in Embryos and Differentiating Embryonic Stem Cells

Published on: October 11, 2012

24.0K
Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer
09:37

Preparing Protein Producing Synthetic Cells using Cell Free Bacterial Extracts, Liposomes and Emulsion Transfer

Published on: April 27, 2020

11.7K

Área de la Ciencia:

  • Biología del desarrollo
  • Biología sintética
  • Ingeniería de Biomateriales

Sus antecedentes:

  • La autoorganización del tejido multicelular se basa en las redes de señalización celular para impulsar cambios morfológicos.
  • Comprender estas redes es clave para descifrar los procesos de desarrollo y diseñar nuevos materiales biológicos.

Objetivo del estudio:

  • Diseñar programas genéticos artificiales utilizando contactos célula-célula para modificar la adhesión celular.
  • Investigar si los programas mínimos de señalización intercelular pueden recapitular las características del desarrollo de los tejidos naturales.

Principales métodos:

  • Utilizó la plataforma de señalización juxtacrina SynNotch para crear redes de comunicación intercelular sintéticas.
  • Programas genéticos diseñados donde los contactos celulares específicos desencadenaron cambios en la adhesión celular mediada por cadherina.

Principales resultados:

  • Logró una autoorganización robusta en estructuras multidominio con ensamblaje secuencial y divergencia de tipo celular.
  • Capacidad demostrada de ruptura de simetría y regeneración en conjuntos de tejidos de ingeniería.
  • Mostró la reorganización espacial inducida por la señal que conduce a la ramificación iterativa del destino celular.

Conclusiones:

  • Los programas mínimos de señalización intercelular pueden impulsar comportamientos complejos de autoorganización observados en el desarrollo natural.
  • La interconexión de la señalización celular con la clasificación celular es un poderoso mecanismo para la formación de estructuras complejas.
  • Estos hallazgos ofrecen información sobre la evolución de la multicelularidad y el potencial para la ingeniería de tejidos personalizados.