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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
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Los ratones transgénicos TCR revelan paso a paso, la adquisición de múltiples sitios del fenotipo distintivo de
Chaoran Li1, Joanna R DiSpirito1, David Zemmour1
1Department of Microbiology and Immunobiology and Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Cell
|June 12, 2018
Resumen
Las células T reguladoras (Treg) en el tejido adiposo visceral (VAT) tienen funciones únicas. Un nuevo modelo de ratón revela cómo se desarrollan y funcionan estas células VAT Treg, ofreciendo información sobre la inflamación y el control del metabolismo.
Área de la Ciencia:
- Inmunología
- Investigación metabólica
- Biología celular
Sus antecedentes:
- El tejido adiposo visceral (VAT) contiene células T reguladoras (Treg) con fenotipos distintos.
- Estas células VAT Treg son cruciales para regular la inflamación y el metabolismo local y sistémico.
- Comprender su origen y función es clave para las estrategias terapéuticas.
Objetivo del estudio:
- Investigar el desarrollo, las dependencias y las actividades de las células Treg del IVA.
- Aclarar el papel de la especificidad de los receptores de células T en la función de las células VAT Treg.
- Descubrir nuevas funciones de los factores y receptores de transcripción en las células VAT Treg.
Principales métodos:
- Generación de una línea de receptor de células T transgénica de ratón con Tregs enriquecidos de VAT.
- Análisis de la procedencia, dependencias y actividades de las células Treg.
- Investigación de las funciones del factor de transcripción (Foxp3) y del receptor (receptor de la interleucina-33).
Principales resultados:
- Se estableció el papel crítico de la especificidad de los receptores de células T en el desarrollo de células VAT Treg.
- Descubrió una nueva función para el factor de transcripción Foxp3 en los Tregs de IVA.
- Se ha demostrado una función intrínseca de la célula para el receptor de la interleucina-33 en la función de VAT Treg.
- Detallado el proceso de dos pasos de la generación de células Treg del IVA: preparación del bazo y diversificación del IVA.
Conclusiones:
- El fenotipo de la célula VAT Treg es el resultado de la preparación del bazo y de las señales microambientales del VAT.
- La especificidad de los receptores de células Treg y los actores moleculares clave como Foxp3 e IL-33R son esenciales para su función.
- Elucidar los principios de la biología de los tejidos Treg es vital para desarrollar terapias dirigidas para enfermedades metabólicas e inflamatorias.
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