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Manejo clínico de la artritis psoriásica

Filip Van den Bosch¹, Laura Coates²

¹Department of Rheumatology, Ghent University Hospital, Ghent, Belgium; VIB Center for Inflammation Research, Unit for Molecular Immunology and Inflammation, Department of Internal Medicine, Ghent University, Ghent, Belgium.

Lancet (London, England)

|June 13, 2018

Resumen

La enfermedad psoriásica es una condición inflamatoria que afecta a la piel y las articulaciones, con una carga significativa para el paciente. El diagnóstico y el tratamiento tempranos son vitales para evitar daños y discapacidades a largo plazo.

Área de la Ciencia:

Reumatología y Dermatología
Enfermedades inflamatorias y autoinmunes

Sus antecedentes:

La enfermedad psoriásica, que abarca la artritis psoriásica, es un trastorno inflamatorio de varios órganos.
Se presenta con afectación de la piel y las articulaciones, manifestaciones extraarticulares y comorbilidades, lo que conlleva una carga clínica sustancial.
El diagnóstico y el tratamiento oportunos son fundamentales para prevenir daños estructurales irreversibles, discapacidad e impacto socioeconómico.

Objetivo del estudio:

Destacar la importancia de la identificación y el diagnóstico tempranos de la enfermedad psoriásica.
Discutir el impacto de la evolución de las opciones terapéuticas en la toma de decisiones clínicas.
Esbozar las direcciones actuales de la investigación en el manejo de la enfermedad psoriásica.

Principales métodos:

Revisión de la comprensión y el tratamiento actuales de la enfermedad psoriásica.
Análisis del papel de los fármacos avanzados, incluidos los biológicos y los sintéticos dirigidos.
Exploración de estrategias de tratamiento emergentes como el tratamiento dirigido y la inducción de la remisión.

Principales resultados:

La enfermedad psoriásica tiene un impacto significativo en la calidad de vida de los pacientes y genera costes socioeconómicos.
Los nuevos fármacos antirreumáticos modificadores de la enfermedad han transformado los paradigmas de tratamiento.
Un enfoque holístico que considere el cuadro clínico completo es esencial para el tratamiento racional.

Conclusiones:

La intervención temprana en la enfermedad psoriásica es primordial para mitigar las consecuencias a largo plazo.
El panorama terapéutico para la enfermedad psoriásica ha avanzado significativamente.
La investigación futura se centra en optimizar las estrategias de tratamiento para mejorar los resultados de los pacientes.

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