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La señalización de la GPCR en el cerebro in vivo aclarada por la fosfoproteómica

Jeffrey J Liu1, Kirti Sharma1, Luca Zangrandi2

  • 1Department of Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, 82152 Martinsried, Germany.

Science (New York, N.Y.)
|June 23, 2018
PubMed
Resumen

Los investigadores utilizaron fosfoproteómicos de alto rendimiento para estudiar la señalización del receptor opioide kappa (KOR). Encontraron que la inhibición de la vía mTOR puede reducir los efectos secundarios relacionados con KOR mientras se mantienen los beneficios terapéuticos.

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