Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

From DNA to Protein03:06

From DNA to Protein

22.5K
The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
22.5K
Encoding01:19

Encoding

867
Information enters the brain through encoding, which is the input of information into the memory system. Once sensory information is received from the environment, the brain labels or codes it. The information is then organized with similar information and connected to existing concepts. Encoding occurs through automatic processing and effortful processing.
Automatic processing involves the encoding of details like time, space, frequency, and the meaning of words, usually done without conscious...
867
DNA-only Transposons02:57

DNA-only Transposons

17.5K
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
17.5K
Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

16.7K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
16.7K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

14.5K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
14.5K
DNA Helicases00:55

DNA Helicases

24.2K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.2K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

A Mesopore-Confined and Graphene Oxide-Localized Ruthenium Catalyst Increases Rates of Mid-Chain Polyolefin Hydrogenolysis.

Journal of the American Chemical Society·2026
Same author

Metal-Phenolic Coatings Enable Universal Design of Spherical Nucleic Acids.

Angewandte Chemie (International ed. in English)·2026
Same author

Strong effect of the nonpolar solvent molecular structure on CdSe nanoplatelet stacking.

Nanoscale·2026
Same author

Programmed synthesis of mesoporous protein crystals in cellular reactors.

Nature nanotechnology·2026
Same author

Correction to "DNA-Mediated Cellular Delivery of Functional Enzymes".

Journal of the American Chemical Society·2026
Same author

Evaluating multi-slice ptychography tomography for X-ray imaging.

Optics express·2026

Video Experimental Relacionado

Updated: Feb 8, 2026

Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles
13:09

Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles

Published on: March 3, 2023

5.2K

Nanopartículas de Janus codificadas por el ADN

Oliver G Hayes, Janet R McMillan, Byeongdu Lee1

  • 1X-ray Science Division , Argonne National Laboratory , Argonne , Illinois 60439 , United States.

Journal of the American Chemical Society
|July 11, 2018
PubMed
Resumen

Los investigadores crearon nanopartículas Janus basadas en proteínas utilizando enlaces de ADN. Estas nuevas nanopartículas se autoensamblan en superredes 3D únicas, lo que permite estructuras de cristal coloidal sintonizables.

Más Videos Relacionados

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

6.6K
Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
09:09

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

10.6K

Videos de Experimentos Relacionados

Last Updated: Feb 8, 2026

Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles
13:09

Demonstration of the DNA Fiber Assay for Investigating DNA Damage and Repair Dynamics Induced by Nanoparticles

Published on: March 3, 2023

5.2K
Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
07:31

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis

Published on: July 16, 2020

6.6K
Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
09:09

Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

Published on: February 27, 2016

10.6K

Área de la Ciencia:

  • Biotecnología
  • Ciencias de los materiales
  • Nanotecnología

Sus antecedentes:

  • Las partículas de Janus ofrecen propiedades únicas debido a su funcionalidad asimétrica.
  • La síntesis de estas partículas no centrosimétricas presenta desafíos significativos.
  • Las proteínas y el ADN proporcionan plataformas versátiles para la ingeniería a nanoescala.

Objetivo del estudio:

  • Para sintetizar nuevas nanopartículas Janus basadas en proteínas.
  • Para explorar el auto-ensamblaje de estas nanopartículas en superredes tridimensionales.
  • Demostrar la compatibilidad de las interacciones mediadas por el ADN para la cristalización coloidal.

Principales métodos:

  • Explotación de la anisotropía química de las proteínas y la química del ADN para la síntesis de nanopartículas.
  • Codificación de proteínas con dominios de ácido nucleico específicos de la secuencia.
  • Utilizando secuencias de oligonucleótidos ortogonales para el enlace de ADN entre partículas.
  • Investigando el autoensamblaje en superredes con arquitecturas de capas hexagonales.

Principales resultados:

  • Síntesis exitosa de nanopartículas Janus basadas en proteínas con enlaces de ADN.
  • Formación de superredes de nanopartículas multicomponentes sin precedentes.
  • Demostración de la expansión de la red sintonizable a través de la modulación de los enlaces de ADN.
  • Realización de arquitecturas de capas hexagonales únicas y de baja simetría.

Conclusiones:

  • Las nanopartículas Janus basadas en proteínas son bloques de construcción efectivos para cristales coloidales diseñados.
  • Las nanopartículas codificadas en ADN ofrecen una plataforma versátil para el diseño de materiales avanzados.
  • Este enfoque establece un precedente para aplicaciones en la cristalización coloidal y la nanotecnología.