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Perspectiva mecánica a través de la inhibición irreversible: la ADN polimerasa θ utiliza un sitio activo común para

Daniel J Laverty1, Ifor P Mortimer1, Marc M Greenberg1

  • 1Department of Chemistry , Johns Hopkins University , 3400 North Charles Street , Baltimore , Maryland 21218 , United States.

Journal of the American Chemical Society
|July 13, 2018
PubMed
Resumen

La ADN polimerasa θ (Pol θ), regulada al alza en el cáncer, tiene un residuo clave de lisina (Lys2383) crucial tanto para sus actividades de polimerasa como de liasa, ofreciendo un objetivo potencial para el desarrollo de fármacos contra el cáncer.

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