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Descubrimiento de una maquinaria de formación de hidrazina sin precedentes en las bacterias

Kenichi Matsuda^1,2, Takeo Tomita^1,3, Kazuo Shin-Ya^1,4

¹Biotechnology Research Center , The University of Tokyo , Tokyo 113-8657 , Japan.

Journal of the American Chemical Society

|July 13, 2018

Resumen

Los investigadores descubrieron una nueva vía bacteriana para la síntesis de hidrazina, un componente clave en el producto natural s56-p1. Este hallazgo revela una capacidad bacteriana no reconocida anteriormente para producir este enlace químico único.

Área de la Ciencia:

La bioquímica
Biosíntesis de productos naturales
Microbiología

Sus antecedentes:

La formación de enlaces nitrógeno-nitrógeno es crucial en la biosíntesis de productos naturales.
Los conocimientos existentes se centran principalmente en rutas biosintéticas específicas.
La biosíntesis de las hidrazinas en la naturaleza sigue siendo en gran medida inexplorada.

Objetivo del estudio:

Para identificar el mecanismo biosintético responsable de la formación de hidrazina en s56-p1.
Investigar la prevalencia y el origen de esta nueva vía biosintética.

Principales métodos:

Análisis bioinformático de los grupos de genes asociados con s56-p1.
Genómica comparativa en las filas bacterianas.
Análisis filogenético de las cintas de genes identificadas.

Principales resultados:

Identificación de una caja genética única que codifica el mecanismo para la formación de hidrazina.
Demostración de la participación de este mecanismo en la biosíntesis del dipeptido s56-p1.
La cinta de genes se encuentra extendida a través de diversos filos bacterianos.

Conclusiones:

Se ha elucidado una nueva vía para la biosíntesis de hidrazina bacteriana.
Este descubrimiento pone de relieve el potencial pasado por alto de las bacterias en la síntesis de hidrazina.
La amplia distribución sugiere funciones ecológicas o evolutivas significativas para las hidrazinas bacterianas.

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