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Updated: Feb 7, 2026
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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
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Probióticos para prevenir la infección por Clostridium difficile en pacientes que reciben antibióticos
Joshua Z Goldenberg1,2, Dominik Mertz3, Bradley C Johnston4
1Bastyr University Research Institute, Kenmore, Washington.
JAMA
|July 21, 2018
Resumen
Los probióticos pueden reducir el riesgo de infección por Clostridium difficile cuando se toman con antibióticos. La evidencia sugiere que los probióticos también están asociados con menos eventos adversos en comparación con el placebo.
Área de la Ciencia:
- Microbiología
- Enfermedades infecciosas
- Gastroenterología
Sus antecedentes:
- El uso de antibióticos es un factor de riesgo importante para la infección por Clostridium difficile (CDI).
- Los probióticos son microorganismos vivos destinados a proporcionar beneficios para la salud, a menudo utilizados para restaurar el equilibrio de la microbiota intestinal.
Objetivo del estudio:
- Evaluar si la administración conjunta de probióticos con antibióticos reduce el riesgo de infección sintomática por Clostridium difficile en adultos y niños.
- Evaluar si los probióticos aumentan el riesgo de eventos adversos cuando se usan simultáneamente con antibióticos.
Principales métodos:
- Revisión sistemática y metanálisis de ensayos controlados aleatorios.
- Incluir estudios en los que se han prescrito antibióticos a poblaciones de adultos y niños.
- Comparación de la administración concomitante de probióticos con el placebo o sin tratamiento.
Principales resultados:
- La evidencia de calidad moderada indica que los probióticos están asociados con un riesgo significativamente menor de desarrollar una infección por Clostridium difficile.
- La evidencia de muy baja calidad sugiere que los probióticos pueden estar asociados con menos eventos adversos en comparación con el placebo o ningún tratamiento.
Conclusiones:
- La suplementación con probióticos parece ser una estrategia segura y efectiva para reducir la incidencia de la infección por Clostridium difficile asociada a los antibióticos.
- Se necesitan más investigaciones de alta calidad para confirmar el perfil de seguridad y aclarar plenamente los beneficios de los probióticos en este contexto.
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