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Desafíos y avances recientes en el descubrimiento de fármacos para las enfermedades tropicales
Manu De Rycker1, Beatriz Baragaña1, Suzanne L Duce2
1Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee, UK.
Nature
|July 27, 2018
Resumen
El desarrollo de nuevos medicamentos para las enfermedades infecciosas tropicales es crucial debido a la alta mortalidad y el impacto económico. Los tratamientos actuales son insuficientes, lo que requiere una investigación urgente y el desarrollo de terapias efectivas.
Área de la Ciencia:
- La medicina tropical
- Enfermedades infecciosas
- Desarrollo de drogas
Sus antecedentes:
- Las enfermedades infecciosas tropicales causan mortalidad, morbilidad y tensión económica significativas, afectando desproporcionadamente a las poblaciones empobrecidas.
- Las intervenciones farmacéuticas existentes son inadecuadas para muchas de estas enfermedades prevalentes.
- Hay una necesidad crítica no satisfecha de nuevos agentes terapéuticos para combatir estas enfermedades descuidadas.
Objetivo del estudio:
- Revisar los retos asociados con el desarrollo de nuevos medicamentos para las enfermedades infecciosas tropicales.
- Para resaltar los avances recientes y el progreso en este campo.
- Subrayar la necesidad constante de estrategias de tratamiento innovadoras.
Principales métodos:
- Revisión de la literatura sobre la investigación y el desarrollo actuales en terapias de enfermedades tropicales.
- Análisis de los obstáculos en el descubrimiento de fármacos y la traducción clínica para enfermedades desatendidas.
- Síntesis de los éxitos recientes y los obstáculos restantes en el campo.
Principales resultados:
- Sigue habiendo desafíos significativos en el proceso de desarrollo de nuevos fármacos para enfermedades tropicales.
- Se han logrado avances recientes, pero sigue existiendo una brecha sustancial entre las capacidades actuales y las necesidades terapéuticas.
- La carga económica y el impacto en la salud subrayan la urgencia de seguir innovando.
Conclusiones:
- A pesar de los notables éxitos, el desarrollo de tratamientos eficaces para las enfermedades infecciosas tropicales sigue siendo un proceso complejo y largo.
- La inversión y la investigación continuas son esenciales para superar los desafíos existentes y ofrecer terapias muy necesarias.
- Abordar el impacto sanitario y económico global requiere esfuerzos sostenidos en el descubrimiento y desarrollo de medicamentos.
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