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Las lectinas modulan la microbiota de las amebas sociales

Christopher Dinh^1,2, Timothy Farinholt¹, Shigenori Hirose¹

¹Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

Science (New York, N.Y.)

|July 28, 2018

Resumen

Las lectinas, como la discoidina I, ayudan a la ameba social Dictyostelium discoideum a administrar su microbioma bacteriano. Esta interacción mediada por la lectina puede extenderse a las células animales, influyendo en la estabilidad del microbioma en los eucariotas.

Área de la Ciencia:

Microbiología
Biología celular
Biología evolutiva

Sus antecedentes:

La ameba social Dictyostelium discoideum alberga un microbioma bacteriano durante su ciclo de vida.
Las bacterias se encuentran dentro de las amebas, las esporas y las babosas migratorias, lo que indica interacciones complejas.

Objetivo del estudio:

Investigar el papel de la lectina discoidina I en el establecimiento del microbioma de Dictyostelium discoideum.
Explorar si el manejo bacteriano mediado por lectinas influye en la transferencia de ADN y la endosimbiosis.
Evaluar el potencial de las lectinas heterólogas para inducir endosimbiosis en células animales.

Principales métodos:

Estudiar el transporte bacteriano y la endosimbiosis en Dictyostelium discoideum.
Investigación de los efectos de la discoidina I y las lectinas vegetales en las interacciones bacterianas.
Analizando la transferencia de ADN entre bacterias y amebas.

Principales resultados:

La discoidina I se une a las bacterias, mejora su supervivencia y altera su retención dentro del Dictyostelium.
Las lectinas vegetales inducen un manejo bacteriano similar, lo que lleva a la transferencia de ADN.
La respuesta celular del dictiostelio a las bacterias está modulada por lectinas, estableciendo su microbioma.

Conclusiones:

Las lectinas son reguladores clave del microbioma de Dictyostelium discoideum.
La manipulación bacteriana inducida por la lectina y la potencial endosimbiosis pueden ocurrir en las células animales.
Las lectinas probablemente juegan un papel importante en la homeostasis del microbioma a través de la evolución eucariota.

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