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Updated: Feb 7, 2026

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El cambio conformacional inducido por la autometilación en Clr4 (Suv39h) mantiene la estabilidad epigenética

Nahid Iglesias1,2, Mark A Currie1,2, Gloria Jih1,2

  • 1Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Nature
|July 28, 2018
PubMed
Resumen

Los investigadores descubrieron cómo la H3K9 metiltransferasa Clr4 es intrínsecamente inhibida y auto-activada. Esta regulación evita el silenciamiento genético aberrante y mantiene la estabilidad epigenética, un mecanismo conservado en los humanos.

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