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El efecto de los antiácidos en la absorción del hierro ingerido simultáneamente
JAMA
|March 21, 1986
Resumen
Ciertos antiácidos, como los que contienen hidróxido de aluminio y hidróxido de magnesio, no inhiben significativamente la absorción de hierro. Sin embargo, el bicarbonato de sodio y el carbonato de calcio pueden reducir la absorción de hierro, a menos que se combinen con vitamina C en un multivitamínico.
Área de la Ciencia:
- La bioquímica es la bioquímica.
- Farmacología Farmacología.
- Nutrición clínica La nutrición clínica es la nutrición clínica.
Sus antecedentes:
- La anemia por deficiencia de hierro es un problema de salud mundial muy frecuente.
- El uso simultáneo de suplementos de hierro con antiácidos es común, pero controvertido en cuanto a la eficacia.
- La literatura existente sugiere la inhibición potencial de la absorción de hierro por los antiácidos.
Objetivo del estudio:
- Para investigar el impacto de los antiácidos comunes en la absorción de hierro.
- Para determinar si las formulaciones específicas de antiácidos afectan la biodisponibilidad del hierro.
- Proporcionar orientación basada en la evidencia sobre la administración conjunta de hierro y antiácidos.
Principales métodos:
- Se empleó una prueba de tolerancia al hierro en dosis pequeñas.
- Se comparó la absorción de hierro con y sin varios antiácidos.
- Se midieron los niveles de hierro en plasma para evaluar las tasas de absorción.
Principales resultados:
- Los antiácidos líquidos que contienen hidróxido de aluminio y hidróxido de magnesio no mostraron una reducción significativa en la absorción de hierro.
- El bicarbonato de sodio y el carbonato de calcio disminuyeron significativamente el aumento de hierro en el plasma en un 50% y 67%, respectivamente.
- El carbonato de calcio en una tableta multivitamínica no inhibió la absorción de hierro, probablemente debido a la presencia de ácido ascórbico.
Conclusiones:
- No todos los antiácidos interfieren con la absorción del hierro.
- La formulación y la presencia de otros ingredientes (por ejemplo, vitamina C) pueden mitigar los efectos inhibidores.
- Los antiácidos específicos pueden administrarse con seguridad junto con la terapia de hierro sin comprometer la eficacia.
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